ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Segregation of Visual Response Properties in the Mouse Superior Colliculus and Their Modulation during Locomotion.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 100 citations in OpenAlex.
- Evolutionarily old brainstem neurons are required for the control of selective spatial attention.Nature communications · 2026Article
- Multiple groups of neurons in the superior colliculus convert value signals into saccadic vigor.iScience · 2026Article
- Population decoding of sound source location by receptive field neurons in the mouse superior colliculus.bioRxiv : the preprint server for biology · 2026Article
- Orientation Maps in Mouse Superior Colliculus Explained by Population Model of Non-Orientation Selective Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Neural dynamics in superior colliculus of freely moving mice.Cell reports · 2025Article
- Differential topographic organization and retinal inheritance of direction and orientation selectivity in the visual thalamus.Nature communications · 2025Article
- Coordination of distinct sources of excitatory inputs enhances motion selectivity in the mouse visual thalamus.Neuron · 2025Article
- Characterization of Auditory Responsive Neurons in the Mouse Superior Colliculus to White Noise and Frequency-Restricted Sounds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Behavioral Modulation and Molecular Definition of Wide-Field Vertical Cells in the Mouse Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
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- Chilean brush-tailed mouse (Journal of neurophysiology · 2025Article
- Genetically defined neuron types underlying visuomotor transformation in the superior colliculus.Nature reviews. Neuroscience · 2024Review
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- Top-down modulation of the retinal code via histaminergic neurons of the hypothalamus.Science advances · 2024Article
- Article
- Stimulus-dependent differences in cortical versus subcortical contributions to visual detection in mice.Current biology : CB · 2024Article
- Predation without direction selectivity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Reward Modulates Visual Responses in the Superficial Superior Colliculus of Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Collicular circuits supporting the perceptual, motor and cognitive demands of ethological environments.Current opinion in neurobiology · 2023Review
- Retinal input integration in excitatory and inhibitory neurons in the mouse superior colliculus in vivo.eLife · 2023Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The superior colliculus (SC) receives direct input from the retina and integrates it with information about sound, touch, and state of the animal that is relayed from other parts of the brain to initiate specific behavioral outcomes. The superficial SC layers (sSC) contain cells that respond to visual stimuli, whereas the deep SC layers (dSC) contain cells that also respond to auditory and somatosensory stimuli. Here, we used a large-scale silicon probe recording system to examine the visual response properties of SC cells of head-fixed and alert male mice. We found cells with diverse response properties including: (1) orientation/direction-selective (OS/DS) cells with a firing rate that is suppressed by drifting sinusoidal gratings (negative OS/DS cells); (2) suppressed-by-contrast cells; (3) cells with complex-like spatial summation nonlinearity; and (4) cells with Y-like spatial summation nonlinearity. We also found specific response properties that are enriched in different depths of the SC. The sSC is enriched with cells with small RFs, high evoked firing rates (FRs), and sustained temporal responses, whereas the dSC is enriched with the negative OS/DS cells and with cells with large RFs, low evoked FRs, and transient temporal responses. Locomotion modulates the activity of the SC cells both additively and multiplicatively and changes the preferred spatial frequency of some SC cells. These results provide the first description of the negative OS/DS cells and demonstrate that the SC segregates cells with different response properties and that the behavioral state of a mouse affects SC activity.
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