Evidence map›Paper›PMID 28760813›Full record

ArticleDevelopment (Cambridge, England)2017

The extracellular metalloprotease AdamTS-A anchors neural lineages in place within and preserves the architecture of the central nervous system.

James B Skeath, Beth A Wilson, Selena E Romero, Mark J Snee, Yi Zhu, Haluk Lacin

Open access · greenAbstract read
In one paragraph

Article in Development (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
  2. Article
  3. The life cycle of type IV collagen.Matrix biology : journal of the International Society for Matrix Biology · 2025
    Review
  4. Article
  5. Basement membrane patterning by spatial deployment of a secretion-regulating protease.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Role ofmicroPublication biology · 2025
    Article
  7. Article
  8. Article
  9. Glia as Functional Barriers and Signaling Intermediaries.Cold Spring Harbor perspectives in biology · 2024
    Review
  10. Review
  11. Article
  12. Drosophila glia take shape to sculpt the nervous system.Current opinion in neurobiology · 2023
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

James B SkeathDepartment of Genetics, Washington University School of Medicine, 4523 Clayton Avenue, St Louis, MO 63110, USA jskeath@genetics.wustl.edu.ORCID 0000-0003-1179-4857
Beth A WilsonDepartment of Genetics, Washington University School of Medicine, 4523 Clayton Avenue, St Louis, MO 63110, USA.
Selena E RomeroDepartment of Genetics, Washington University School of Medicine, 4523 Clayton Avenue, St Louis, MO 63110, USA.
Mark J SneeDepartment of Genetics, Washington University School of Medicine, 4523 Clayton Avenue, St Louis, MO 63110, USA.
Yi ZhuDepartment of Genetics, Washington University School of Medicine, 4523 Clayton Avenue, St Louis, MO 63110, USA.
Haluk LacinJanelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA.
Washington University in St. Louis · USHoward Hughes Medical Institute · US

Funding

THE ROLE OF ADAMTS-A IN REGULATING CNS STRUCTURE AND RESTRICTING CELL MIGRATIONR01NS036570 · NINDS · WASHINGTON UNIVERSITY · PI SKEATH, JAMES BENJAMIN · 1997 to 2021
$6.4M
OPPORTUNITIES IN GENOMICS RESEARCH: INCREASING DIVERSITY AND RETENTION IN STEMR25HG006687 · NHGRI · WASHINGTON UNIVERSITY · PI MITRA, ROBI D, SKEATH, JAMES BENJAMIN · 2012 to 2025
$4.1M
NHGRI NIH HHS R25 HG006687NINDS NIH HHS R01 NS036570
6 · The paper itself

Abstract

The extracellular matrix (ECM) regulates cell migration and sculpts organ shape. AdamTS proteins are extracellular metalloproteases known to modify ECM proteins and promote cell migration, but demonstrated roles for AdamTS proteins in regulating CNS structure and ensuring cell lineages remain fixed in place have not been uncovered. Using forward genetic approaches in

Indexed as

Cell LineageAllelesAnimalsBasement MembraneCentral Nervous SystemCollagen Type IVDrosophila melanogasterDrosophila ProteinsExtracellular MatrixGreen Fluorescent ProteinsIntegrin alpha ChainsMutationNeurogliaNeuronsPhenotypeSubcellular FractionsCollagen Type IVDrosophila ProteinsGreen Fluorescent Proteinsif protein, DrosophilaIntegrin alpha ChainsAdamTS proteinsCell migrationCollagen IVExtra-cellular matrixGlia

Identifiers

PMID28760813
PMCPMC5611953
OpenAlexW2740792175

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.