ArticleCirculation research2017
SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Circulation research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
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31citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
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Who cites it
31 citing papers in PubMed, 50 citations in OpenAlex.
- KAP1 SUMOylates and stabilizes SR-A to facilitate glycated LDL transcytosis and accelerate atherosclerosis.Cellular & molecular biology letters · 2026Article
- SUMOylation is destined for regulatory T cell-related immune dysregulation.Cell death discovery · 2026Review
- Reduced SUMOylation impairs NOTCH3 signaling and cell survival in the pathogenesis of CADASIL.Cell communication and signaling : CCS · 2025Article
- SENP1: A perspective from immune cells to disease (Review).Oncology reports · 2025Review
- SUMOylation substrate encoding genes as prognostic biomarkers in pancreatic ductal adenocarcinoma with functional assessment ofFrontiers in pharmacology · 2025Article
- SRF SUMOylation modulates smooth muscle phenotypic switch and vascular remodeling.Nature communications · 2024Article
- Crosstalk between SUMOylation and other post-translational modifications in breast cancer.Cellular & molecular biology letters · 2024Review
- SUMOylation Fine-Tunes Endothelial HEY1 in the Regulation of Angiogenesis.Circulation research · 2024Article
- Emerging role of SENP1 in tumorigenesis and cancer therapy.Frontiers in pharmacology · 2024Review
- Review
- KnockdownBiomedicines · 2023Article
- M6AREG: m6A-centered regulation of disease development and drug response.Nucleic acids research · 2023Article
- VEGF combined with DAPT promotes tissue regeneration and remodeling in vascular grafts.Regenerative biomaterials · 2023Article
- The Notch signaling-regulated angiogenesis in rheumatoid arthritis: pathogenic mechanisms and therapeutic potentials.Frontiers in immunology · 2023Review
- The role of SUMOylation in the neurovascular dysfunction after acquired brain injury.Frontiers in pharmacology · 2023Review
- SENP2 Promotes VSMC Phenotypic Switching via Myocardin De-SUMOylation.International journal of molecular sciences · 2022Article
- FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Review: Myelin clearance is critical for regeneration after peripheral nerve injury.Frontiers in neurology · 2022Review
- Review
- Wrestling and Wrapping: A Perspective on SUMO Proteins in Schwann Cells.Biomolecules · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 4 institutions in 3 countries.
Xiaolong ZhuFrom the Institute of Genetics and Regenerative Biology, College of Life Sciences (X.Z., S.D., C.Q., Y. Shi, L.S., Yueyue Wang, Yuewen Wang, J.L., Yiran Wang, Y. Sun, L.Y.), Research Center for Air Pollution and Health (X.Z., S.D., C.Q., Y. Shi, L.S., Yuewen Wang, J.L., Yiran Wang, L.Y.), and Key Laboratory for Molecular Animal Nutrition, Ministry of Education, Innovation Center for Cell Signaling Network, College of Life Sciences (J.C.), Zhejiang University, Hangzhou, China; Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (L.Q., M.S.); Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT (L.Q., W.M.); and The First Affiliated Hospital, Center for Translational Medicine, Sun Yat-sen University, Guangzhou, China (W.M.).
Sha DingFrom the Institute of Genetics and Regenerative Biology, College of Life Sciences (X.Z., S.D., C.Q., Y. Shi, L.S., Yueyue Wang, Yuewen Wang, J.L., Yiran Wang, Y. Sun, L.Y.), Research Center for Air Pollution and Health (X.Z., S.D., C.Q., Y. Shi, L.S., Yuewen Wang, J.L., Yiran Wang, L.Y.), and Key Laboratory for Molecular Animal Nutrition, Ministry of Education, Innovation Center for Cell Signaling Network, College of Life Sciences (J.C.), Zhejiang University, Hangzhou, China; Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (L.Q., M.S.); Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT (L.Q., W.M.); and The First Affiliated Hospital, Center for Translational Medicine, Sun Yat-sen University, Guangzhou, China (W.M.).
Cong QiuFrom the Institute of Genetics and Regenerative Biology, College of Life Sciences (X.Z., S.D., C.Q., Y. Shi, L.S., Yueyue Wang, Yuewen Wang, J.L., Yiran Wang, Y. Sun, L.Y.), Research Center for Air Pollution and Health (X.Z., S.D., C.Q., Y. Shi, L.S., Yuewen Wang, J.L., Yiran Wang, L.Y.), and Key Laboratory for Molecular Animal Nutrition, Ministry of Education, Innovation Center for Cell Signaling Network, College of Life Sciences (J.C.), Zhejiang University, Hangzhou, China; Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (L.Q., M.S.); Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT (L.Q., W.M.); and The First Affiliated Hospital, Center for Translational Medicine, Sun Yat-sen University, Guangzhou, China (W.M.).
Yanna ShiFrom the Institute of Genetics and Regenerative Biology, College of Life Sciences (X.Z., S.D., C.Q., Y. Shi, L.S., Yueyue Wang, Yuewen Wang, J.L., Yiran Wang, Y. Sun, L.Y.), Research Center for Air Pollution and Health (X.Z., S.D., C.Q., Y. Shi, L.S., Yuewen Wang, J.L., Yiran Wang, L.Y.), and Key Laboratory for Molecular Animal Nutrition, Ministry of Education, Innovation Center for Cell Signaling Network, College of Life Sciences (J.C.), Zhejiang University, Hangzhou, China; Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (L.Q., M.S.); Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT (L.Q., W.M.); and The First Affiliated Hospital, Center for Translational Medicine, Sun Yat-sen University, Guangzhou, China (W.M.).
Lin SongFrom the Institute of Genetics and Regenerative Biology, College of Life Sciences (X.Z., S.D., C.Q., Y. Shi, L.S., Yueyue Wang, Yuewen Wang, J.L., Yiran Wang, Y. Sun, L.Y.), Research Center for Air Pollution and Health (X.Z., S.D., C.Q., Y. Shi, L.S., Yuewen Wang, J.L., Yiran Wang, L.Y.), and Key Laboratory for Molecular Animal Nutrition, Ministry of Education, Innovation Center for Cell Signaling Network, College of Life Sciences (J.C.), Zhejiang University, Hangzhou, China; Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (L.Q., M.S.); Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT (L.Q., W.M.); and The First Affiliated Hospital, Center for Translational Medicine, Sun Yat-sen University, Guangzhou, China (W.M.).
Yueyue WangFrom the Institute of Genetics and Regenerative Biology, College of Life Sciences (X.Z., S.D., C.Q., Y. Shi, L.S., Yueyue Wang, Yuewen Wang, J.L., Yiran Wang, Y. Sun, L.Y.), Research Center for Air Pollution and Health (X.Z., S.D., C.Q., Y. Shi, L.S., Yuewen Wang, J.L., Yiran Wang, L.Y.), and Key Laboratory for Molecular Animal Nutrition, Ministry of Education, Innovation Center for Cell Signaling Network, College of Life Sciences (J.C.), Zhejiang University, Hangzhou, China; Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (L.Q., M.S.); Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT (L.Q., W.M.); and The First Affiliated Hospital, Center for Translational Medicine, Sun Yat-sen University, Guangzhou, China (W.M.).
Yuewen WangFrom the Institute of Genetics and Regenerative Biology, College of Life Sciences (X.Z., S.D., C.Q., Y. Shi, L.S., Yueyue Wang, Yuewen Wang, J.L., Yiran Wang, Y. Sun, L.Y.), Research Center for Air Pollution and Health (X.Z., S.D., C.Q., Y. Shi, L.S., Yuewen Wang, J.L., Yiran Wang, L.Y.), and Key Laboratory for Molecular Animal Nutrition, Ministry of Education, Innovation Center for Cell Signaling Network, College of Life Sciences (J.C.), Zhejiang University, Hangzhou, China; Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (L.Q., M.S.); Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT (L.Q., W.M.); and The First Affiliated Hospital, Center for Translational Medicine, Sun Yat-sen University, Guangzhou, China (W.M.).
Jinying LiFrom the Institute of Genetics and Regenerative Biology, College of Life Sciences (X.Z., S.D., C.Q., Y. Shi, L.S., Yueyue Wang, Yuewen Wang, J.L., Yiran Wang, Y. Sun, L.Y.), Research Center for Air Pollution and Health (X.Z., S.D., C.Q., Y. Shi, L.S., Yuewen Wang, J.L., Yiran Wang, L.Y.), and Key Laboratory for Molecular Animal Nutrition, Ministry of Education, Innovation Center for Cell Signaling Network, College of Life Sciences (J.C.), Zhejiang University, Hangzhou, China; Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (L.Q., M.S.); Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT (L.Q., W.M.); and The First Affiliated Hospital, Center for Translational Medicine, Sun Yat-sen University, Guangzhou, China (W.M.).
Yiran WangFrom the Institute of Genetics and Regenerative Biology, College of Life Sciences (X.Z., S.D., C.Q., Y. Shi, L.S., Yueyue Wang, Yuewen Wang, J.L., Yiran Wang, Y. Sun, L.Y.), Research Center for Air Pollution and Health (X.Z., S.D., C.Q., Y. Shi, L.S., Yuewen Wang, J.L., Yiran Wang, L.Y.), and Key Laboratory for Molecular Animal Nutrition, Ministry of Education, Innovation Center for Cell Signaling Network, College of Life Sciences (J.C.), Zhejiang University, Hangzhou, China; Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (L.Q., M.S.); Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT (L.Q., W.M.); and The First Affiliated Hospital, Center for Translational Medicine, Sun Yat-sen University, Guangzhou, China (W.M.).
Yi SunFrom the Institute of Genetics and Regenerative Biology, College of Life Sciences (X.Z., S.D., C.Q., Y. Shi, L.S., Yueyue Wang, Yuewen Wang, J.L., Yiran Wang, Y. Sun, L.Y.), Research Center for Air Pollution and Health (X.Z., S.D., C.Q., Y. Shi, L.S., Yuewen Wang, J.L., Yiran Wang, L.Y.), and Key Laboratory for Molecular Animal Nutrition, Ministry of Education, Innovation Center for Cell Signaling Network, College of Life Sciences (J.C.), Zhejiang University, Hangzhou, China; Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (L.Q., M.S.); Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT (L.Q., W.M.); and The First Affiliated Hospital, Center for Translational Medicine, Sun Yat-sen University, Guangzhou, China (W.M.).
Lingfeng QinFrom the Institute of Genetics and Regenerative Biology, College of Life Sciences (X.Z., S.D., C.Q., Y. Shi, L.S., Yueyue Wang, Yuewen Wang, J.L., Yiran Wang, Y. Sun, L.Y.), Research Center for Air Pollution and Health (X.Z., S.D., C.Q., Y. Shi, L.S., Yuewen Wang, J.L., Yiran Wang, L.Y.), and Key Laboratory for Molecular Animal Nutrition, Ministry of Education, Innovation Center for Cell Signaling Network, College of Life Sciences (J.C.), Zhejiang University, Hangzhou, China; Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (L.Q., M.S.); Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT (L.Q., W.M.); and The First Affiliated Hospital, Center for Translational Medicine, Sun Yat-sen University, Guangzhou, China (W.M.).
Jun ChenFrom the Institute of Genetics and Regenerative Biology, College of Life Sciences (X.Z., S.D., C.Q., Y. Shi, L.S., Yueyue Wang, Yuewen Wang, J.L., Yiran Wang, Y. Sun, L.Y.), Research Center for Air Pollution and Health (X.Z., S.D., C.Q., Y. Shi, L.S., Yuewen Wang, J.L., Yiran Wang, L.Y.), and Key Laboratory for Molecular Animal Nutrition, Ministry of Education, Innovation Center for Cell Signaling Network, College of Life Sciences (J.C.), Zhejiang University, Hangzhou, China; Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (L.Q., M.S.); Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT (L.Q., W.M.); and The First Affiliated Hospital, Center for Translational Medicine, Sun Yat-sen University, Guangzhou, China (W.M.).
Michael SimonsFrom the Institute of Genetics and Regenerative Biology, College of Life Sciences (X.Z., S.D., C.Q., Y. Shi, L.S., Yueyue Wang, Yuewen Wang, J.L., Yiran Wang, Y. Sun, L.Y.), Research Center for Air Pollution and Health (X.Z., S.D., C.Q., Y. Shi, L.S., Yuewen Wang, J.L., Yiran Wang, L.Y.), and Key Laboratory for Molecular Animal Nutrition, Ministry of Education, Innovation Center for Cell Signaling Network, College of Life Sciences (J.C.), Zhejiang University, Hangzhou, China; Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (L.Q., M.S.); Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT (L.Q., W.M.); and The First Affiliated Hospital, Center for Translational Medicine, Sun Yat-sen University, Guangzhou, China (W.M.).
Wang MinFrom the Institute of Genetics and Regenerative Biology, College of Life Sciences (X.Z., S.D., C.Q., Y. Shi, L.S., Yueyue Wang, Yuewen Wang, J.L., Yiran Wang, Y. Sun, L.Y.), Research Center for Air Pollution and Health (X.Z., S.D., C.Q., Y. Shi, L.S., Yuewen Wang, J.L., Yiran Wang, L.Y.), and Key Laboratory for Molecular Animal Nutrition, Ministry of Education, Innovation Center for Cell Signaling Network, College of Life Sciences (J.C.), Zhejiang University, Hangzhou, China; Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (L.Q., M.S.); Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT (L.Q., W.M.); and The First Affiliated Hospital, Center for Translational Medicine, Sun Yat-sen University, Guangzhou, China (W.M.).
Luyang YuFrom the Institute of Genetics and Regenerative Biology, College of Life Sciences (X.Z., S.D., C.Q., Y. Shi, L.S., Yueyue Wang, Yuewen Wang, J.L., Yiran Wang, Y. Sun, L.Y.), Research Center for Air Pollution and Health (X.Z., S.D., C.Q., Y. Shi, L.S., Yuewen Wang, J.L., Yiran Wang, L.Y.), and Key Laboratory for Molecular Animal Nutrition, Ministry of Education, Innovation Center for Cell Signaling Network, College of Life Sciences (J.C.), Zhejiang University, Hangzhou, China; Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (L.Q., M.S.); Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT (L.Q., W.M.); and The First Affiliated Hospital, Center for Translational Medicine, Sun Yat-sen University, Guangzhou, China (W.M.). luyangyu@zju.edu.cn.
Sun Yat-sen University · CNYale University · USThe First Affiliated Hospital, Sun Yat-sen University · CNYangon University of Economics · MM
Funding
The role of signaling molecule AIP1 in pathological angiogenesisR01HL115148 · NHLBI · YALE UNIVERSITY · PI KYRIAKIDES, THEMIS R · 2013 to 2021
$3.6MSTRESS SIGNALING PATHWAYS LINKING ENDOTHELIAL INJURY TO GRAFT ARTERIOSCLEROSISR01HL109420 · NHLBI · YALE UNIVERSITY · PI POBER, JORDAN S · 2012 to 2020
$3.3MCCM3-mediated exocytosis in pathogenesis of cerebral cavernous malformationR01HL136507 · NHLBI · YALE UNIVERSITY · PI STERN, DAVID F · 2017 to 2020
$1.9MNHLBI NIH HHS R01 HL109420NHLBI NIH HHS R01 HL115148NHLBI NIH HHS R01 HL136507
Abstract
rationaleThe highly conserved NOTCH (neurogenic locus notch homolog protein) signaling pathway functions as a key cell-cell interaction mechanism controlling cell fate and tissue patterning, whereas its dysregulation is implicated in a variety of developmental disorders and cancers. The pivotal role of endothelial NOTCH in regulation of angiogenesis is widely appreciated; however, little is known about what controls its signal transduction. Our previous study indicated the potential role of post-translational SUMO (small ubiquitin-like modifier) modification (SUMOylation) in vascular disorders.
objectiveThe aim of this study was to investigate the role of SUMOylation in endothelial NOTCH signaling and angiogenesis. METHODS AND
resultsEndothelial SENP1 (sentrin-specific protease 1) deletion, in newly generated endothelial
conclusionsThese results establish reversible NOTCH1 SUMOylation as a regulatory mechanism in coordinating endothelial angiogenic signaling; SENP1 acts as a critical intrinsic mediator of this process. These findings may apply to NOTCH-regulated biological events in nonvascular tissues and provide a novel therapeutic strategy for vascular diseases and tumors.
Indexed as
Neovascularization, PhysiologicSumoylationAdaptor Proteins, Signal TransducingAnimalsBinding SitesCalcium-Binding ProteinsCells, CulturedCysteine EndopeptidasesEndopeptidasesHumansHuman Umbilical Vein Endothelial CellsIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceProtein BindingReceptors, NotchAdaptor Proteins, Signal TransducingCalcium-Binding ProteinsCysteine EndopeptidasesDLL4 protein, mouseEndopeptidasesIntracellular Signaling Peptides and ProteinsMembrane ProteinsReceptors, NotchReceptors, Vascular Endothelial Growth FactorSenp1 protein, mouseangiogenesisNOTCH1SENP1SUMOylation
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