Evidence map›Paper›PMID 28760774›Full record

ArticleMolecular and cellular biology2017

Unperturbed Immune Function despite Mutation of C-Terminal Tyrosines in Syk Previously Implicated in Signaling and Activity Regulation.

Vanessa Weis, Sebastian Königsberger, Susanne Amler, Jürgen Wienands, Friedemann Kiefer

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Vanessa WeisMax Planck Institute for Molecular Biomedicine, Mammalian Cell Signaling Laboratory, Münster, Germany.
Sebastian KönigsbergerMax Planck Institute for Molecular Biomedicine, Mammalian Cell Signaling Laboratory, Münster, Germany.
Susanne AmlerInstitute of Biostatistics and Clinical Research, Westfälischen Wilhelms-Universität Münster, Münster, Germany.
Jürgen WienandsUniversitätsmedizin Göttingen, Georg-August-Universität, Abt. Zelluläre und Molekulare Immunologie, Göttingen, Germany.
Friedemann KieferMax Planck Institute for Molecular Biomedicine, Mammalian Cell Signaling Laboratory, Münster, Germany fkiefer@gwdg.de.
Max Planck Institute for Molecular Biomedicine · DEUniversity of Münster · DEUniversitätsmedizin Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The nonreceptor tyrosine kinase Syk, a central regulator of immune cell differentiation and activation, is a promising drug target for treatment of leukemia and allergic and inflammatory diseases. The clinical failure of Syk inhibitors underscores the importance of understanding the regulation of Syk function and activity. A series of previous studies emphasized the importance of three C-terminal tyrosines in Syk for kinase activity regulation, as docking sites for downstream effector molecules, and for Ca

Indexed as

MutationAnimalsB-LymphocytesCell DifferentiationCell LineGene Knock-In TechniquesHumansMast CellsMicePhenylalanineSignal TransductionSyk KinaseTyrosinePhenylalanineSyk KinaseSYK protein, humanSyk protein, mouseTyrosineBCR signalingimmunoreceptorsmast cellssignal transductionSyk

Identifiers

PMID28760774
PMCPMC5640812
OpenAlexW2740220093

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.