Evidence map›Paper›PMID 28760081›Full record

ArticleThe Journal of international medical research2018

Plasma concentrations of ascorbic acid in a cross section of the German population.

Alexander F Hagel, Heinz Albrecht, Wolfgang Dauth, Wolfgang Hagel, Francesco Vitali, Ingo Ganzleben, Hans W Schultis, Peter C Konturek, Jürgen Stein, Markus F Neurath and 1 more

Open access · goldAbstract read
In one paragraph

Article in The Journal of international medical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 87 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Alexander F Hagel1 Department of Medicine 1, University of Erlangen - Nuremberg, Germany.
Heinz Albrecht1 Department of Medicine 1, University of Erlangen - Nuremberg, Germany.
Wolfgang Dauth2 Institute of Employment Research, Nuremberg, Germany.
Wolfgang Hagel3 Department of Medicine 6, Paracelsus Medical University, Nuremberg, Germany.
Francesco Vitali1 Department of Medicine 1, University of Erlangen - Nuremberg, Germany.
Ingo Ganzleben1 Department of Medicine 1, University of Erlangen - Nuremberg, Germany.
Hans W Schultis4 Synlab, Weiden, Germany.
Peter C Konturek5 Thuringia Clinics, Gastroenterology, Saalfeld, Germany.
Jürgen Stein6 Department of Nutritional Medicine, Sachsenhausen University Hospital, Frankfurt/Main, Germany.
Markus F Neurath1 Department of Medicine 1, University of Erlangen - Nuremberg, Germany.
Martin Raithel1 Department of Medicine 1, University of Erlangen - Nuremberg, Germany.
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEGoethe University Frankfurt · DEInstitut für Arbeitsmarkt und Berufsforschung · DEParacelsus Medizinische Privatuniversität · DESynlab (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives Vitamin C deficiency is considered extremely rare in modern industrialized countries. This study was performed to assess vitamin C concentrations in the German population. Methods As part of a consultant-patient seminar on nutrition and food intolerances, patients were asked to participate in this study on a voluntary basis. Blood samples were taken for analysis of serum vitamin C concentrations, and all patients were asked to complete a questionnaire. The vitamin C concentration was determined by high-performance liquid chromatography. Results Of approximately 300 patients attending the seminar, 188 (62.6%) consented to vitamin C blood sample analysis and 178 (59.3%) answered the questionnaire. The mean vitamin C concentration was 7.98 mg/L (range, 0.50-17.40; reference range, 5-15 mg/L). A low plasma level with vitamin C insufficiency (<5 mg/L) was found in 31 patients (17.4%), and a potential scorbutogenic deficiency (<1.5 mg/L) was found in 6 (3.3%). Conclusions Potential vitamin C insufficiency and deficiency is common. It is therefore possible, even in modern developed populations, that certain individuals may require a higher intake of vitamin C.

Indexed as

Surveys and QuestionnairesAdultAgedAged, 80 and overAge FactorsAscorbic AcidAscorbic Acid DeficiencyBody Mass IndexCross-Sectional StudiesFemaleGermanyHumansIncidenceMaleMiddle AgedSex FactorsAscorbic Acidascorbic acidbody mass indexdeficiencyscurvyVitamin C

Identifiers

PMID28760081
PMCPMC6011295
OpenAlexW2740708809

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.