ArticlePloS one2017
Glutamate/GABA+ ratio is associated with the psychosocial domain of autistic and schizotypal traits.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Dopamine Dysregulation in Reward and Autism Spectrum Disorder.Brain sciences · 2024Review
- Article
- The impact of spectral basis set composition on estimated levels of cingulate glutamate and its associations with different personality traits.BMC psychiatry · 2024Article
- Reduced MMN-indexed auditory change detection in a non-clinical high schizotypy sample.Personality neuroscience · 2024Article
- Metabolic Adverse Effects of Psychotropic Drug Therapy: A Systematic Review.European journal of investigation in health, psychology and education · 2023Review
- Association between increased anterior cingulate glutamate and psychotic-like experiences, but not autistic traits in healthy volunteers.Scientific reports · 2023Article
- Article
- Inhibiting silence information regulator 2 and glutaminase in the amygdala can improve social behavior in autistic rats.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2022Article
- MicroRNA-139-5p acts as a suppressor gene for depression by targeting nuclear receptor subfamily 3, group C, member 1.Bioengineered · 2022Article
- The Relationship Between Affective Visual Mismatch Negativity and Interpersonal Difficulties Across Autism and Schizotypal Traits.Frontiers in human neuroscience · 2022Article
- Prediction learning in adults with autism and its molecular correlates.Molecular autism · 2021Article
- Tumor metabolism and neurocognition in CNS lymphoma.Neuro-oncology · 2021Article
- ACC Glu/GABA ratio is decreased in euthymic bipolar disorder I patients: possible in vivo neurometabolite explanation for mood stabilization.European archives of psychiatry and clinical neuroscience · 2021Article
- Drinking water temperature affects cognitive function and progression of Alzheimer's disease in a mouse model.Acta pharmacologica Sinica · 2021Article
- Comparison of the Metabolic Profiles in the Plasma and Urine Samples Between Autistic and Typically Developing Boys: A Preliminary Study.Frontiers in psychiatry · 2021Article
- Excitation-inhibition balance and auditory multistable perception are correlated with autistic traits and schizotypy in a non-clinical population.Scientific reports · 2020Article
- Association between Anterior Cingulate Neurochemical Concentration and Individual Differences in Hypnotizability.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- The Neurochemistry of Autism.Brain sciences · 2020Article
- Oxaloacetate reduces emotional symptoms in premenstrual syndrome (PMS): results of a placebo-controlled, cross-over clinical trial.Obstetrics & gynecology science · 2020Article
- The P1 visual-evoked potential, red light, and transdiagnostic psychiatric symptoms.Brain research · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe autism and schizophrenia spectra overlap to a large degree in the social and interpersonal domains. Similarly, abnormal excitatory glutamate and inhibitory γ-aminobutyric acid (GABA) neurotransmitter concentrations have been reported for both spectra, with the interplay of these neurotransmitters important for cortical excitation to inhibition regulation. This study investigates whether these neurotransmitter abnormalities are specific to the shared symptomatology, and whether the degree of abnormality increases with increasing symptom severity. Hence, the relationship between the glutamate/GABA ratio and autism and schizophrenia spectrum traits in an unmedicated, subclinical population was investigated.
methodsA total of 37 adults (19 female, 18 male) aged 18-38 years completed the Autism Spectrum Quotient (AQ) and Schizotypal Personality Questionnaire (SPQ), and participated in the resting state proton magnetic resonance spectroscopy study in which sequences specific for quantification of glutamate and GABA+ concentration were applied to a right and left superior temporal voxel.
resultsThere were significant, moderate, positive relationships between right superior temporal glutamate/GABA+ ratio and AQ, SPQ and AQ+SPQ total scores (p<0.05), SPQ subscales Social Anxiety, No Close Friend, Constricted Affect, Odd Behaviour, Odd Speech, Ideas of Reference and Suspiciousness, and AQ subscales Social Skills, Communication and Attention Switching (p<0.05); increased glutamate/GABA+ coinciding with higher scores on these subscales. Only the relationships between glutamate/GABA+ ratio and Social Anxiety, Constricted Affect, Social Skills and Communication survived multiple comparison correction (p< 0.004). Left superior temporal glutamate/GABA+ ratio reduced with increasing restricted imagination (p<0.05).
conclusionThese findings demonstrate evidence for an association between excitatory/inhibitory neurotransmitter concentrations and symptoms that are shared between the autism and schizophrenia spectra.
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