ArticlePLoS neglected tropical diseases2017
Risk factors for inadequate antibody response to primary rabies vaccination in dogs under one year of age.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Comparing Rabies Antibody Titres in Imported Dogs to a Population of Dogs in Ontario, Canada.Zoonoses and public health · 2025Article
- The Challenge of Lyssavirus Infections in Domestic and Other Animals: A Mix of Virological Confusion, Consternation, Chagrin, and Curiosity.Pathogens (Basel, Switzerland) · 2025Review
- Bayesian modeling of post-vaccination serological data suggests that yearly vaccination of dog aged <2 years old is efficient to stop rabies circulation in Cambodia.PLoS neglected tropical diseases · 2024Article
- Does Perioperative Administration of Rabies Vaccine in Dogs Undergoing Surgical Sterilization Induce an Adequate Antibody Response?Vaccines · 2023Article
- Dog Population Rabies Immunity before a Mass Vaccination Campaign in Lima, Peru: Vulnerabilities for Virus Reestablishment.The American journal of tropical medicine and hygiene · 2023Article
- Effect of Aging on the Immune Response to Core Vaccines in Senior and Geriatric Dogs.Veterinary sciences · 2023Article
- Risk of Rabies and Implications for Postexposure Prophylaxis Administration in the US.JAMA network open · 2023Article
- Assessment of Immune Responses to Rabies Vaccination in Free-Ranging Dogs in Bengaluru, India.Vaccines · 2023Article
- Evaluation of the immune response of dogs after a mass vaccination campaign against rabies in Tunisia.BMC veterinary research · 2023Article
- Risks related to a possible reduction of the waiting period for dogs after rabies antibody titration to 30 days compared with 90 days of the current EU legislative regime.EFSA journal. European Food Safety Authority · 2022Article
- Rabies in a Dog Imported from Azerbaijan - Pennsylvania, 2021.MMWR. Morbidity and mortality weekly report · 2022Article
- Investigation of protective level of rabies antibodies in vaccinated dogs in Chennai, India.Veterinary record open · 2021Article
- Loss of binding antibodies against rabies in a vaccinated dog population in Flores Island, Indonesia.PLoS neglected tropical diseases · 2021Article
- Negligible risk of rabies importation in dogs thirty days after demonstration of adequate serum antibody titer.Vaccine · 2021Article
- Rabies Vaccination of 6-Week-Old Puppies Born to Immunized Mothers: A Randomized Controlled Trial in a High-Mortality Population of Owned, Free-Roaming Dogs.Tropical medicine and infectious disease · 2020Article
- Article
- Risk assessment on rabies entry through hunting dog movement with semi-quantitative approach to Sumatera Island, Indonesia.Journal of advanced veterinary and animal research · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ensuring the adequacy of response to rabies vaccination in dogs is important, particularly in the context of pet travel. Few studies have examined the factors associated with dogs' failure to achieve an adequate antibody titer after vaccination (0.5 IU/ml). This study evaluated rabies antibody titers in dogs after primary vaccination. Dogs under one year of age whose serum was submitted to a reference laboratory for routine diagnostics, and which had no prior documented history of vaccination were enrolled (n = 8,011). Geometric mean titers (GMT) were calculated and univariate analysis was performed to assess factors associated with failure to achieve 0.5 IU/mL. Dogs vaccinated at >16 weeks of age had a significantly higher GMT compared to dogs vaccinated at a younger age (1.64 IU/ml, 1.57-1.72, ANOVA p < 0.01). There was no statistical difference in GMT between dogs vaccinated <12 weeks and dogs vaccinated 12-16 weeks (1.22 IU/ml and 1.21 IU/ml). The majority of dogs failed to reach an adequate titer within the first 3 days of primary vaccination; failure rates were also high if the interval from vaccination to titer check was greater than 90 days. Over 90% of dogs that failed primary vaccination were able to achieve adequate titers after booster vaccination. The ideal timing for blood draw is 8-30 days after primary vaccination. In the event of a failure, most dogs will achieve an adequate serologic response upon a repeat titer (in the absence of booster vaccination). Booster vaccination after failure provided the highest probability of an acceptable titer.
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