ArticlePloS one2017
Chicken hepatic response to chronic heat stress using integrated transcriptome and metabolome analysis.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it, 136 citations in OpenAlex.
- Global trends and research frontiers on heat stress in poultry from 2000 to 2021: A bibliometric analysis.Frontiers in physiology · 2023Pooled it
- Integrative transcriptomic analysis reveals tissue associated molecular responses to heat stress in chickens.Poultry science · 2026Article
- A Review on Heat Stress in Broiler Chickens: Mechanisms, Effects and Mitigation Strategies.Veterinary medicine and science · 2026Review
- Livestock immunogenomics based on omics integration: from infection and stress to xenotransplantation.Journal of animal science and technology · 2026Review
- Noninvasive Epidermal Mucus RNA-Seq Analysis for Developing Methods to Evaluate Environmental Stress in the Japanese Eel (Anguilla japonica).Marine biotechnology (New York, N.Y.) · 2026Article
- Salicylic acid supplementation for broiler chickens under heat stress.Open veterinary journal · 2025Review
- Integrative transcriptomics and metabolomics reveal neuroendocrine-lipid crosstalk and adenosine signaling in broiler under heat stress.BMC genomics · 2025Article
- Comparative transcriptomic analysis reveals the important role of hepatic fatty acid metabolism in the acute heat stress response in chickens.BMC genomics · 2025Article
- Chronic heat stress facilitates lipoprotein lipase expression and triglyceride biosynthesis in the adipose tissue of growing broiler chickens.Scientific reports · 2025Article
- Major Oxidative and Antioxidant Mechanisms During Heat Stress-Induced Oxidative Stress in Chickens.Antioxidants (Basel, Switzerland) · 2025Review
- In ovo betaine and heat acclimation affect hatching results, growth performance and immunity of the broilers under cyclic heat stress.Tropical animal health and production · 2024Article
- Green Light Mitigates Cyclic Chronic Heat-Stress-Induced Liver Oxidative Stress and Inflammation via NF-κB Pathway Inhibition in Geese.Antioxidants (Basel, Switzerland) · 2024Article
- Article
- Metabolomics and transcriptomics of embryonic livers reveal hypoxia adaptation of Tibetan chickens.BMC genomics · 2024Article
- Effects of Heat Stress on Breast Muscle Metabolomics and Lipid Metabolism Related Genes in Growing Broilers.Animals : an open access journal from MDPI · 2024Article
- Genomic regions and biological mechanisms underlying climatic resilience traits derived from automatically-recorded vaginal temperature in lactating sows under heat stress conditions.Frontiers in genetics · 2024Article
- Effect of dietary betaine supplementation on the liver transcriptome profile in broiler chickens under heat stress conditions.Animal bioscience · 2023Article
- Influence of different heat stress models on nutrient digestibility and markers of stress, inflammation, lipid, and protein metabolism in broilers.Poultry science · 2023Article
- Transcriptome analysis of multiple tissues reveals the potential mechanism of death under acute heat stress in chicken.BMC genomics · 2023Article
- Chicken pituitary transcriptomic responses to acute heat stress.Molecular biology reports · 2023Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The liver plays a central role in metabolism and is important in maintaining homeostasis throughout the body. This study integrated transcriptomic and metabolomic data to understand how the liver responds under chronic heat stress. Chickens from a rapidly growing broiler line were heat stressed for 8 hours per day for one week and liver samples were collected at 28 days post hatch. Transcriptome analysis reveals changes in genes responsible for cell cycle regulation, DNA replication, and DNA repair along with immune function. Integrating the metabolome and transcriptome data highlighted multiple pathways affected by heat stress including glucose, amino acid, and lipid metabolism along with glutathione production and beta-oxidation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.