Evidence map›Paper›PMID 28759388›Full record

ReviewThe Lancet. Oncology2017

Genomic approaches to accelerate cancer interception.

Jennifer Beane, Joshua D Campbell, Julian Lel, Jessica Vick, Avrum Spira

Abstract readReview
In one paragraph

Review in The Lancet. Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Review
  7. Australian Attitudes Towards Waivers of Consent Within the Context of Genomic Data Sharing.Journal of empirical research on human research ethics : JERHRE · 2024
    Article
  8. Article
  9. Review
  10. Early Detection of Ovarian Cancer.Cold Spring Harbor perspectives in medicine · 2023
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jennifer BeaneDepartment of Medicine and BU-BMC Cancer Center, Boston University, Boston, MA, USA.
Joshua D CampbellDepartment of Medicine and BU-BMC Cancer Center, Boston University, Boston, MA, USA.
Julian LelDepartment of Medicine and BU-BMC Cancer Center, Boston University, Boston, MA, USA.
Jessica VickDepartment of Medicine and BU-BMC Cancer Center, Boston University, Boston, MA, USA.
Avrum SpiraDepartment of Medicine and BU-BMC Cancer Center, Boston University, Boston, MA, USA. Electronic address: aspira@bu.edu.

Funding

BIOLOGY OF THE LUNG--MULTIDISCIPLINARY PROGRAMT32HL007035 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Darrell N. Kotton, JOSEPH P MIZGERD · 1985 to 2026
$24.3M
Molecular and Imaging Biomarkers for Early Lung Cancer Detection in the Setting of Indeterminate Pulmonary NodulesR01CA210360 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ABERLE, DENISE R., LENBURG, MARC ELLIOTT · 2016 to 2021
$3.1M
The Boston University-UCLA Lung Cancer Biomarker Development LabU01CA214182 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ABERLE, DENISE R., DUBINETT, STEVEN M. · 2016 to 2021
$3.1M
NCI NIH HHS R01 CA210360NCI NIH HHS U01 CA214182NHLBI NIH HHS T32 HL007035
6 · The paper itself

Abstract

Although major advances have been reported in the last decade in the treatment of late-stage cancer with targeted and immune-based therapies, there is a crucial unmet need to develop new approaches to improve the prevention and early detection of cancer. Advances in genomics and computational biology offer unprecedented opportunities to understand the earliest molecular events associated with carcinogenesis, enabling novel strategies to intercept the development of invasive cancers. This Series paper will highlight emerging big data genomic approaches with the potential to accelerate advances in cancer prevention, screening, and early detection across various tumour types, and the challenges inherent in the development of these tools for clinical use. Through coordinated multicentre consortia, these genomic approaches are likely to transform the landscape of cancer interception in the coming years.

Indexed as

Early Detection of CancerGenomicsBiomarkers, TumorGenetic Predisposition to DiseaseGenetic TestingHumansNeoplasmsPrecancerous ConditionsBiomarkers, Tumor

Identifiers

PMID28759388
PMCPMC6020676

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.