ArticleGut microbes2018
Vasopressin deletion is associated with sex-specific shifts in the gut microbiome.
Article in Gut microbes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- PMProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Piglet cardiopulmonary bypass induces intestinal dysbiosis and barrier dysfunction associated with systemic inflammation.Disease models & mechanisms · 2023Article
- Article
- Gut Inflammation Induced by Finasteride Withdrawal: Therapeutic Effect of Allopregnanolone in Adult Male Rats.Biomolecules · 2022Article
- Functional Plasmon-Activated Water IncreasesInternational journal of molecular sciences · 2022Article
- Gut Barrier Dysfunction and Type 2 Immunity: Implications for Compulsive Behavior.Medical hypotheses · 2022Article
- Exploring the Impact of the Microbiome on Neuroactive Steroid Levels in Germ-Free Animals.International journal of molecular sciences · 2021Article
- Arginine vasopressin and pathophysiology of COVID-19: An innovative perspective.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021Review
- Alterations of gut microbiota composition in post-finasteride patients: a pilot study.Journal of endocrinological investigation · 2021Article
- Birth signalling hormones and the developmental consequences of caesarean delivery.Journal of neuroendocrinology · 2021Review
- The role of the microbiome in the neurobiology of social behaviour.Biological reviews of the Cambridge Philosophical Society · 2020Article
- Microbial transmission in animal social networks and the social microbiome.Nature ecology & evolution · 2020Review
- Post-finasteride syndrome: An emerging clinical problem.Neurobiology of stress · 2020Article
- Oxytocin and Vasopressin Systems in Obesity and Metabolic Health: Mechanisms and Perspectives.Current obesity reports · 2019Review
- Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits.Cell metabolism · 2019Article
- Sustained Captopril-Induced Reduction in Blood Pressure Is Associated With Alterations in Gut-Brain Axis in the Spontaneously Hypertensive Rat.Journal of the American Heart Association · 2019Article
- Dynamic Development of Fecal Microbiome During the Progression of Diabetes Mellitus in Zucker Diabetic Fatty Rats.Frontiers in microbiology · 2019Article
- Defining Dysbiosis in Disorders of Movement and Motivation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Review
- Sex differences in metabolism and cardiometabolic disorders.Current opinion in lipidology · 2018Review
- Steroids, stress and the gut microbiome-brain axis.Journal of neuroendocrinology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Brattleboro rats harbor a spontaneous deletion of the arginine-vasopressin (Avp) gene. In addition to diabetes insipidus, these rats exhibit low levels of anxiety and depressive behaviors. Recent work on the gut-brain axis has revealed that gut microbiota can influence anxiety behaviors. Therefore, we studied the effects of Avp gene deletion on gut microbiota. Since Avp gene expression is sexually different, we also examined how Avp deletion affects sex differences in gut microbiota. Males and females show modest but differentiated shifts in taxa abundance across 3 separate Avp deletion genotypes: wildtype (WT), heterozygous (Het) and AVP-deficient Brattleboro (KO) rats. For each sex, we found examples of taxa that have been shown to modulate anxiety behavior, in a manner that correlates with anxiety behavior observed in homozygous knockout Brattleboro rats. One prominent example is Lactobacillus, which has been reported to be anxiolytic: Lactobacillus was found to increase in abundance in inverse proportion to increasing gene dosage (most abundant in KO rats). This genotype effect of Lactobacillus abundance was not found when females were analyzed independently. Therefore, Avp deletion appears to affect microbiota composition in a sexually differentiated manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.