ArticleOncogene2017
Role of HSPA1L as a cellular prion protein stabilizer in tumor progression via HIF-1α/GP78 axis.
Abstract read
In one paragraph
Article in Oncogene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 43 citations in OpenAlex.
- PrPInternational journal of molecular sciences · 2026Article
- High cellular prion protein expression in cholangiocarcinoma: A marker for early postoperative recurrence and unfavorable prognosis.World journal of gastrointestinal surgery · 2025Article
- VEGFR3 mitigates hypertensive nephropathy by enhancing mitophagy via regulating crotonylation of HSPA1L.Cell communication and signaling : CCS · 2025Article
- Predicting patient outcomes with gene-expression biomarkers from colorectal cancer organoids and cell lines.Frontiers in molecular biosciences · 2025Article
- Oncogenic potential of SARS-CoV-2-targeting hallmarks of cancer pathways.Cell communication and signaling : CCS · 2024Review
- Profiling the Hsp70 Chaperone Network in Heat-Induced Proteotoxic Stress Models of Human Neurons.Biology · 2023Article
- Melatonin and 5-fluorouracil combination chemotherapy: opportunities and efficacy in cancer therapy.Cell communication and signaling : CCS · 2023Review
- Cellular Prion Protein Is Closely Associated with Early Recurrence and Poor Survival in Patients with Hepatocellular Carcinoma.Diagnostics (Basel, Switzerland) · 2022Article
- The E3 Ubiquitin Ligase TRAF6 Interacts with the Cellular Prion Protein and Modulates Its Solubility and Recruitment to Cytoplasmic p62/SQSTM1-Positive Aggresome-Like Structures.Molecular neurobiology · 2022Article
- Downregulated PRNP Facilitates Cell Proliferation and Invasion and Has Effect on the Immune Regulation in Ovarian Cancer.Journal of immunology research · 2022Article
- Acidic and Hypoxic Microenvironment in Melanoma: Impact of Tumour Exosomes on Disease Progression.Cells · 2021Review
- The Cellular Prion Protein and the Hallmarks of Cancer.Cancers · 2021Review
- Tumor Necrosis Factor α Reduces SNAP29 Dependent Autolysosome Formation to Increase Prion Protein Level and Promote Tumor Cell Migration.Virologica Sinica · 2021Article
- The expression profiles and prognostic values of HSP70s in hepatocellular carcinoma.Cancer cell international · 2021Article
- Prion Protein of Extracellular Vesicle Regulates the Progression of Colorectal Cancer.Cancers · 2021Article
- The Role of Cellular Prion Protein in Promoting Stemness and Differentiation in Cancer.Cancers · 2021Review
- Long Noncoding RNA NONHSAT079852.2 Contributes to GBM Recurrence by Functioning as a ceRNA for has-mir-10401-3p to Facilitate HSPA1A Upregulation.Frontiers in oncology · 2021Article
- The Cellular Prion Protein: A Promising Therapeutic Target for Cancer.International journal of molecular sciences · 2020Review
- HSPA1L Enhances Cancer Stem Cell-Like Properties by Activating IGF1Rβ and Regulating β-Catenin Transcription.International journal of molecular sciences · 2020Article
- Comparative Analysis of Milk Fat Globular Membrane (MFGM) Proteome between Saudi ArabiaMolecules (Basel, Switzerland) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 2 countries.
J H LeeDepartment of Pharmacology and Toxicology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Y-S HanMedical Science Research Institute, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea.
Y M YoonMedical Science Research Institute, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea.
C W YunMedical Science Research Institute, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea.
S P YunNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
S M KimNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
H Y KwonSoonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, Republic of Korea.
D JeongDepartment of Pathology, Collage of Medicine, Soonchunhyang University, Cheonan, Republic of Korea.
M J BaekDepartment of Surgery, Collage of Medicine, Soonchunhyang University, Cheonan, Republic of Korea.
H J LeeDepartment of Veterinary Physiology, College of Veterinary Medicine and Research Institute for Veterinary Science, and BK21 PLUS Creative Veterinary Research Center, Seoul National University, Seoul, Republic of Korea.
S-J LeeDepartment of Veterinary Physiology, College of Veterinary Medicine and Research Institute for Veterinary Science, and BK21 PLUS Creative Veterinary Research Center, Seoul National University, Seoul, Republic of Korea.
H J HanDepartment of Veterinary Physiology, College of Veterinary Medicine and Research Institute for Veterinary Science, and BK21 PLUS Creative Veterinary Research Center, Seoul National University, Seoul, Republic of Korea.
S H LeeMedical Science Research Institute, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea.
Seoul National University · KRSoonchunhyang University · KRJohns Hopkins University · USSoonchunhyang University Hospital · KRUniversity of Alabama at Birmingham · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cellular prion protein (PrP
Indexed as
CarcinogenesisCell Culture TechniquesColorectal NeoplasmsDisease ProgressionFlow CytometryGene Knockdown TechniquesHSP70 Heat-Shock ProteinsHT29 CellsHumansHypoxia-Inducible Factor 1, alpha SubunitMolecular Targeted TherapyPrion ProteinsProteasome Endopeptidase ComplexProteolysisReceptors, Autocrine Motility FactorRNA InterferenceAMFR protein, humanHIF1A protein, humanHSP70 Heat-Shock ProteinsHSPA1L protein, humanHypoxia-Inducible Factor 1, alpha SubunitPrion ProteinsProteasome Endopeptidase ComplexReceptors, Autocrine Motility FactorRNA, Small Interfering
Identifiers
What OpenQuestion holds
Textmetadata
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.