Evidence map›Paper›PMID 28758966›Full record

Trial reportInternational journal of molecular sciences2017

Variability of Creatine Metabolism Genes in Children with Autism Spectrum Disorder.

Jessie M Cameron, Valeriy Levandovskiy, Wendy Roberts, Evdokia Anagnostou, Stephen Scherer, Alvin Loh, Andreas Schulze

Open access · goldAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jessie M CameronGenetics and Genome Biology, Peter Gilgan Center for Research and Learning, Toronto, ON M5G 0A4, Canada. jessie.cameron@sickkids.ca.
Valeriy LevandovskiyGenetics and Genome Biology, Peter Gilgan Center for Research and Learning, Toronto, ON M5G 0A4, Canada. Valeriy.Levandovskiy@sickkids.ca.
Wendy RobertsDepartment of Paediatrics, University of Toronto, Toronto, ON M5S 1A1, Canada. wendy.roberts@sickkids.ca.
Evdokia AnagnostouDepartment of Paediatrics, University of Toronto, Toronto, ON M5S 1A1, Canada. Evdokia.Anagnostou@sickkids.ca.
Stephen SchererGenetics and Genome Biology, Peter Gilgan Center for Research and Learning, Toronto, ON M5G 0A4, Canada. Stephen.Scherer@sickkids.ca.
Alvin LohDepartment of Paediatrics, University of Toronto, Toronto, ON M5S 1A1, Canada. Alvin.Loh@SurreyPlace.on.ca.
Andreas SchulzeGenetics and Genome Biology, Peter Gilgan Center for Research and Learning, Toronto, ON M5G 0A4, Canada. andreas.schulze@sickkids.ca.
University of Toronto · CACentre for Global Health Research · CASurrey Place Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Creatine deficiency syndrome (CDS) comprises three separate enzyme deficiencies with overlapping clinical presentations: arginine:glycine amidinotransferase (

Indexed as

Genetic VariationAmidinotransferasesAutism Spectrum DisorderChildChild, PreschoolCreatinineFemaleGuanidinoacetate N-MethyltransferaseHumansMaleNerve Tissue ProteinsPlasma Membrane Neurotransmitter Transport ProteinsProspective StudiesAmidinotransferasesCreatinineGAMT protein, humanglycine amidinotransferaseGuanidinoacetate N-MethyltransferaseNerve Tissue ProteinsPlasma Membrane Neurotransmitter Transport ProteinsSLC6A8 protein, humanautism spectrum disordercreatine deficiency syndromegenetic variabilityglycine amidinotransferaseguanidinoacetate methyltransferasesolute carrier family 6 member 8

Identifiers

PMID28758966
PMCPMC5578055
OpenAlexW2739593690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.