Evidence map›Paper›PMID 28758896›Full record

ArticleAging2017

Chemo brain or tumor brain - that is the question: the presence of extracranial tumors profoundly affects molecular processes in the prefrontal cortex of TumorGraft mice.

Anna Kovalchuk, Yaroslav Ilnytskyy, Rocio Rodriguez-Juarez, Svitlana Shpyleva, Stepan Melnyk, Igor Pogribny, Amanda Katz, David Sidransky, Olga Kovalchuk, Bryan Kolb

Open access · greenAbstract read
In one paragraph

Article in Aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Cancer and dementia: Two sides of the same coin?European journal of clinical investigation · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Anna KovalchukDepartment of Neuroscience, University of Lethbridge, Lethbridge, AB T1K 6T5, Canada.
Yaroslav IlnytskyyDepartment of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 6T5, Canada.
Rocio Rodriguez-JuarezDepartment of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 6T5, Canada.
Svitlana ShpylevaDivision of Biochemical Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA.
Stepan MelnykDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Igor PogribnyDivision of Biochemical Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA.
Amanda KatzDepartment of Oncology, Champions Oncology, Baltimore, MD 21205, USA.
David SidranskyDepartment of Oncology, Champions Oncology, Baltimore, MD 21205, USA.
Olga KovalchukDepartment of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 6T5, Canada.
Bryan KolbDepartment of Neuroscience, University of Lethbridge, Lethbridge, AB T1K 6T5, Canada.
University of Lethbridge · CAChampions Oncology (United States) · USNational Center for Toxicological Research · USUniversity of Arkansas for Medical Sciences · USUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer chemotherapy causes numerous persistent central nervous system complications. This condition is known as chemo brain. Cognitive impairments occur even before treatment, and hence are referred to as

Indexed as

Prefrontal CortexAnimalsAntineoplastic AgentsBrain NeoplasmsBreast NeoplasmsCognitive DysfunctionDNA MethylationDNA Modification MethylasesFemaleHumansMiceNeoplasms, ExperimentalOxidative StressReceptors, ProgesteroneAntineoplastic AgentsDNA Modification MethylasesReceptors, Progesteroneagingchemo brainDNA methylationgene expressiontumor brain

Identifiers

PMID28758896
PMCPMC5559168
OpenAlexW2741760679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.