ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018
Complement Gene Expression Correlates with Superior Frontal Cortical Thickness in Humans.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Exploration of Novel Biomarkers Through a Precision Medicine Approach Using Multi-Omics and Brain Organoids in Patients With Atypical Depression and Psychotic Symptoms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Integrative transcriptomic and proteomic analysis reveals that SERPING1 inhibits neuronal proliferationWorld journal of psychiatry · 2025Article
- Spatial multiomics of arterial regions from cardiac allograft vasculopathy rejected grafts reveal novel insights into the pathogenesis of chronic antibody-mediated rejection.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024Article
- Use of Extracellular Monomeric Ubiquitin as a Therapeutic Option for Major Depressive Disorder.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Common risk alleles for schizophrenia within the major histocompatibility complex predict white matter microstructure.Translational psychiatry · 2024Article
- Correlation between frailty and reduction in cortical thickness in patients with chronic obstructive pulmonary disease.Scientific reports · 2024Article
- Changes in the Dentate Gyrus Gene Expression Profile Induced by Levetiracetam Treatment in Rats with Mesial Temporal Lobe Epilepsy.International journal of molecular sciences · 2024Article
- Serping1 associated with α-synuclein increase in colonic smooth muscles of MPTP-induced Parkinson's disease mice.Scientific reports · 2024Article
- Multiomic approach and Mendelian randomization analysis identify causal associations between blood biomarkers and subcortical brain structure volumes.NeuroImage · 2023Article
- Multiomic approach and Mendelian randomization analysis identify causal associations between blood biomarkers and subcortical brain structure volumes.medRxiv : the preprint server for health sciences · 2023Article
- Complement Activation Products in Patients with Chronic Schizophrenia.Journal of clinical medicine · 2023Article
- Serum complement proteins rather than inflammatory factors is effective in predicting psychosis in individuals at clinical high risk.Translational psychiatry · 2023Article
- Dysregulation of complement system in neuropsychiatric disorders: A mini review.Biomarkers in neuropsychiatry · 2022Article
- Aberrant Complement System Activation in Neurological Disorders.International journal of molecular sciences · 2021Review
- Schizophrenia: Complement Cleaning or Killing.Genes · 2021Review
- Deciphering microbiome and neuroactive immune gene interactions in schizophrenia.Neurobiology of disease · 2020Review
- Complement System in Brain Architecture and Neurodevelopmental Disorders.Frontiers in neuroscience · 2020Review
- The schizophrenia and bipolar twin study in Sweden (STAR).Schizophrenia research · 2019Article
- Commentary: Beyond C4: Analysis of the complement gene pathway shows enrichment for IQ in patients with psychotic disorders and healthy controls.Frontiers in immunology · 2019Article
- Autoimmune phenotypes in schizophrenia reveal novel treatment targets.Pharmacology & therapeutics · 2018Review
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Recent work suggests that genes encoding complement proteins that are active in the innate immune system may confer risk for schizophrenia by disrupting typical synaptic pruning in late adolescence. Alterations in the complement pathway may contribute to aberrant cortical thinning in schizophrenia prodromes and reduced prefrontal cortical thickness in chronic schizophrenia patients; however, this theory needs to be translated to humans. We conducted a series of analyses in a sample of adult Swedish twins enriched for schizophrenia (N=129) to assess the plausibility of a relationship between complement gene expression and cortical thickness that could go awry in the etiology of schizophrenia. First, we identified that peripheral mRNA expression levels of two complement genes (C5, SERPING1) made unique contributions to the variance in superior frontal cortical thickness among all participants. Vertex-wise maps of the association between gene expression levels and thickness across the cortex suggested that this relationship was especially strong with SERPING1 in the superior frontal region, consistent with the pattern of disruption in cortical thickness observed in schizophrenia. Additional analyses identified that these genes are expressed in the human superior frontal cortex, that heritable genetic factors influence SERPING1 gene expression levels, and that these associations are observed regardless of case status. These findings provide initial evidence linking the complement system with cortical thinning in humans, a process potentially involved in the pathogenesis of schizophrenia.
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Registered trials
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