Evidence map›Paper›PMID 28758384›Full record

ArticleACS sensors2017

Nanoelectronic Discrimination of Nonmalignant and Malignant Cells Using Nanotube Field-Effect Transistors.

Guilherme O Silva, Zachary P Michael, Long Bian, Galina V Shurin, Marcelo Mulato, Michael R Shurin, Alexander Star

Abstract read
In one paragraph

Article in ACS sensors, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Size-Based Norfentanyl Detection with SWCNT@UiO-MOF Composites.ACS applied materials & interfaces · 2024
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Carbon Nanotube Chemical Sensors.Chemical reviews · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Guilherme O SilvaDepartment of Chemistry, University of Pittsburgh , 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260, United States.
Zachary P MichaelDepartment of Chemistry, University of Pittsburgh , 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260, United States.
Long BianDepartment of Chemistry, University of Pittsburgh , 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260, United States.
Galina V ShurinDepartment of Pathology, University of Pittsburgh Medical Center , 3550 Terrace Street, Pittsburgh, Pennsylvania 15261, United States.
Marcelo MulatoDepartment of Physics, Faculty of Philosophy, Science and Letters at Ribeirão Preto, University of São Paulo , Avenida Bandeirantes 3900, Ribeirão Preto, São Paulo 14040-401, Brazil.
Michael R ShurinDepartment of Pathology, University of Pittsburgh Medical Center , 3550 Terrace Street, Pittsburgh, Pennsylvania 15261, United States.
Alexander StarDepartment of Chemistry, University of Pittsburgh , 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260, United States.ORCID http://orcid.org/0000-0001-7863-5987

Funding

Investigations and Mitigation of Carbon Nanomaterial ToxicityR01ES019304 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STAR, ALEXANDER · 2010 to 2014
$1.9M
NIEHS NIH HHS R01 ES019304
6 · The paper itself

Abstract

Detection of malignant cells in tissue is a difficult hurdle in medical diagnostics and screening. Carbon nanotubes are extremely sensitive to their local environments, and nanotube-based field-effect transistors (NTFETs) provide a plethora of information regarding the mechanism of interaction with target analytes. Herein, we use a series of functionalized metal nanoparticle-decorated NTFET devices forming an array with multiple nonselective sensor units as the electronic "tongue", sensing all five basic tastes. By extraction of selected NTFET characteristics and using linear discriminant analysis, we have successfully detected and discriminated between malignant and nonmalignant tissues and cells. We also studied the sensing mechanism and what NTFET characteristics are responsible for the variation of response between cell types, allowing for the design of future studies such as detection of malignant cells in a biopsy or the effects of malignant cells on healthy tissue.

Indexed as

biosensorscarbon nanotubeselectronic tonguelinear discriminant analysismetal nanoparticle

Identifiers

PMID28758384
PMCPMC6538068

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.