Evidence map›Paper›PMID 28758191›Full record

ArticleImmunology2017

Interleukin-27 signalling induces stem cell antigen-1 expression in T lymphocytes in vivo.

Zhihao Liu, Lisha Wu, Jing Zhu, Xiaotong Zhu, Jianmin Zhu, Jin-Qing Liu, Jianchao Zhang, Jonathan P Davis, Sanjay Varikuti, Abhay R Satoskar and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Zhihao LiuDepartment of Gastroenterology, Guangdong Provincial Key Laboratory of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Lisha WuDepartment of Gastroenterology, Guangdong Provincial Key Laboratory of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jing ZhuDepartment of Gastroenterology, Guangdong Provincial Key Laboratory of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xiaotong ZhuDepartment of Gastroenterology, Guangdong Provincial Key Laboratory of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jianmin ZhuPaediatric Translational Medicine Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jin-Qing LiuDepartment of Pathology and Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA.
Jianchao ZhangDepartment of Physiology, Ohio State University, Columbus, OH, USA.
Jonathan P DavisDepartment of Physiology, Ohio State University, Columbus, OH, USA.
Sanjay VarikutiDepartment of Pathology and Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA.
Abhay R SatoskarDepartment of Pathology and Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA.
Jie ZhouDepartment of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Ming-Song LiDepartment of Gastroenterology, Guangdong Provincial Key Laboratory of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xue-Feng BaiDepartment of Pathology and Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA.ORCID 0000-0001-9476-8376
Nanfang Hospital · CNThe Ohio State University · USShanghai Jiao Tong University · CN

Funding

IL-27-based cancer vaccination approach for cancer immunotherapyR21CA198037 · NCI · OHIO STATE UNIVERSITY · PI BAI, XUE-FENG · 2015 to 2016
$368k
NCI NIH HHS R21 CA198037
6 · The paper itself

Abstract

Stem cell antigen-1 (Sca-1/Ly6A/E) is a cell surface glycoprotein that is often used as a biomarker for stem cells and cell stemness. However, it is not clear what factors can directly induce the expression of Sca-1/Ly6A/E in T lymphocytes in vivo, and if induction of Sca-1 is associated with T cell stemness. In this study, we show that interleukin-27 (IL-27), a member of the IL-12 family of cytokines, directly induces Sca-1 expression in T cells in vivo. We found that mice-deficient for IL-27 (either P28 or EBI3) or its signalling (IL-27Rα) had profound reduction of Sca-1 expression in naive (CD62L

Indexed as

Immunologic MemoryAnimalsAntigens, CDAntigens, LyGene Expression RegulationInterleukinsMembrane ProteinsMiceMice, KnockoutReceptors, CytokineReceptors, InterleukinSignal TransductionT-LymphocytesAntigens, CDAntigens, LyIl27 protein, mouseIl27ra protein, mouseInterleukinsLy6a protein, mouseMembrane ProteinsReceptors, CytokineReceptors, Interleukininterleukin-27stem cell antigen-1T-cell memory

Identifiers

PMID28758191
PMCPMC5680066
OpenAlexW2740168337

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.