Evidence map›Paper›PMID 28758151›Full record

ArticleBiochemistry and biophysics reports2016

The effect of diet-induced serum hypercholesterolemia on the surfactant system and the development of lung injury.

Scott Milos, Joshua Qua Hiansen, Brandon Banaschewski, Yi Y Zuo, Li-Juan Yao, Lynda A McCaig, James Lewis, Cory M Yamashita, Ruud A W Veldhuizen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Scott MilosLawson Health Research Institute, Department of Physiology and Pharmacology, Western University, London, ON, Canada.
Joshua Qua HiansenLawson Health Research Institute, Department of Physiology and Pharmacology, Western University, London, ON, Canada.
Brandon BanaschewskiLawson Health Research Institute, Department of Physiology and Pharmacology, Western University, London, ON, Canada.
Yi Y ZuoDepartment of Mechanical Engineering, University of Hawaii at Manoa, Honolulu, HI, USA.
Li-Juan YaoLawson Health Research Institute, Department of Physiology and Pharmacology, Western University, London, ON, Canada.
Lynda A McCaigLawson Health Research Institute, Department of Physiology and Pharmacology, Western University, London, ON, Canada.
James LewisLawson Health Research Institute, Department of Physiology and Pharmacology, Western University, London, ON, Canada.
Cory M YamashitaLawson Health Research Institute, Department of Physiology and Pharmacology, Western University, London, ON, Canada.
Ruud A W VeldhuizenLawson Health Research Institute, Department of Physiology and Pharmacology, Western University, London, ON, Canada.
Lawson Health Research Institute · CAWestern University · CAUniversity of Hawaiʻi at Mānoa · US

Funding

RESEARCH DESIGN AND BIOSTATISTICS COREU54MD007584 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI MOKUAU, NOREEN, SHIRAMIZU, BRUCE T · 2012 to 2018
$21.1M
NIMHD NIH HHS U54 MD007584
6 · The paper itself

Abstract

Acute respiratory distress syndrome (ARDS) is a pulmonary disorder associated with alterations to the pulmonary surfactant system. Recent studies showed that supra-physiological levels of cholesterol in surfactant contribute to impaired function. Since cholesterol is incorporated into surfactant within the alveolar type II cells which derives its cholesterol from serum, it was hypothesized that serum hypercholesterolemia would predispose the host to the development of lung injury due to alterations of cholesterol content in the surfactant system. Wistar rats were randomized to a standard lab diet or a high cholesterol diet for 17-20 days. Animals were then exposed to one of three models of lung injury: i) acid aspiration ii) ventilation induced lung injury, and iii) surfactant depletion. Following physiological monitoring, lungs were lavaged to obtain and analyze the surfactant system. The physiological results showed there was no effect of the high cholesterol diet on the severity of lung injury in any of the three models of injury. There was also no effect of the diet on surfactant cholesterol composition. Rats fed a high cholesterol diet had a significant impairment in surface tension reducing capabilities of isolated surfactant compared to those fed a standard diet exposed to the surfactant depletion injury. In addition, only rats that were exposed to ventilation induced lung injury had elevated levels of surfactant associated cholesterol compared to non-injured rats. It is concluded that serum hypercholesterolemia does not predispose rats to altered surfactant cholesterol composition or to lung injury. Elevated cholesterol within surfactant may be a marker for ventilation induced lung damage.

Indexed as

ARDSCholesterolPulmonary surfactantSerum hypercholesterolemiaSurface tension

Identifiers

PMID28758151
PMCPMC5527759
OpenAlexW2412755947

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.