Evidence map›Paper›PMID 28758150›Full record

ArticleJournal of nature and science2017

Diabetes and Cardioplegia.

Brittany A Potz, Laura A Scrimgeour, Jun Feng, Frank W Sellke

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of nature and science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Brittany A PotzAlpert Warren Medical School of Brown University, 2 Dudley Street, MOC 360, Providence, RI 02905, USA.
Laura A ScrimgeourAlpert Warren Medical School of Brown University, 2 Dudley Street, MOC 360, Providence, RI 02905, USA.
Jun FengAlpert Warren Medical School of Brown University, 2 Dudley Street, MOC 360, Providence, RI 02905, USA.
Frank W SellkeAlpert Warren Medical School of Brown University, 2 Dudley Street, MOC 360, Providence, RI 02905, USA.
Brown University · US

Funding

Uncoupling of IL-1 beta and VEGF-A Crosstalk Contributes to Impaired Arteriogenesis Response to Ischemia in Chronic Diabetes MellitusP20GM103652 · NIGMS · OCEAN STATE RESEARCH INSTITUTE, INC. · PI CHOUDHARY, GAURAV, HARRINGTON, ELIZABETH O · 2013 to 2022
$21.3M
Effect of Cardioplegia and Cardiopulmonary Bypass on Coronary Microvascular ReactivityR01HL046716 · NHLBI · RHODE ISLAND HOSPITAL · PI SELLKE, FRANK W · 1997 to 2023
$8.5M
Vascular Dysfunction in Myocardial Ischemia and Metabolic SyndromeR01HL128831 · NHLBI · RHODE ISLAND HOSPITAL · PI SELLKE, FRANK W, USHEVA-SIMIDJIYSKA, ANNY · 2016 to 2025
$5.7M
Trauma and Inflammation Research TrainingT32GM065085 · NIGMS · RHODE ISLAND HOSPITAL · PI Alfred Ayala · 2004 to 2026
$3.2M
SKca/IKca Channel Activation and Endothelial Protection During Cardiac SurgeryR01HL136347 · NHLBI · RHODE ISLAND HOSPITAL · PI FENG, JUN · 2017 to 2020
$1.9M
Metabolic Regulation of SKCa/IKCa Channels and Endothelial FunctionR01HL127072 · NHLBI · RHODE ISLAND HOSPITAL · PI FENG, JUN · 2016 to 2019
$1.5M
NHLBI NIH HHS R01 HL046716NHLBI NIH HHS R01 HL127072NHLBI NIH HHS R01 HL128831NHLBI NIH HHS R01 HL136347NIGMS NIH HHS P20 GM103652NIGMS NIH HHS T32 GM065085
6 · The paper itself

Abstract

Cardiac surgery with cardiopulmonary bypass and cardioplegic arrest is associated with injury to the vasculature and microcirculation leading to coronary microvascular dysfunction, permeability changes and cardiac dysfunction. In the setting of cardiopulmonary bypass with cardioplegia, poorly-controlled diabetes is associated with significant changes in endothelium-dependent and independent vascular dysfunction, vascular reactivity, vascular permeability, protein expression, cell death, coronary/peripheral microcirculation and reduced vasomotor tone leading to hypotension and impaired endothelial function. The gene expression profiles after cardiopulmonary bypass with cardioplegic arrest is quantitatively and qualitatively different in patients with diabetes. Gene expression profiling capitalizing on the differences between patients with and without diabetes is a good place to identify potential medical targets.

Indexed as

Cardiac SurgeryCardioplegiaDiabetes

Identifiers

PMID28758150
PMCPMC5533287
OpenAlexW2625031627

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.