ArticleChemical science2015
Target-fueled DNA walker for highly selective miRNA detection.
Article in Chemical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 130 citations in OpenAlex.
- Review
- Pushing Forward the DNA Walkers in Connection with Tumor-Derived Extracellular Vesicles.International journal of nanomedicine · 2024Review
- Nucleic acid nanoassembly-enhanced RNA therapeutics and diagnosis.Acta pharmaceutica Sinica. B · 2023Review
- Review
- DNA Walkers for Biosensing Development.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Electrochemiluminescence biosensor based on molybdenum disulfide-graphene quantum dots nanocomposites and DNA walker signal amplification for DNA detection.Mikrochimica acta · 2021Article
- Integrated nicking enzyme-powered numerous-legged DNA walker prepared by rolling circle amplification for fluorescence detection of microRNA.Mikrochimica acta · 2021Article
- A bipedal DNA nanowalker fueled by catalytic assembly for imaging of base-excision repairing in living cells.Chemical science · 2020Article
- A well-directional three-dimensional DNA walking nanomachine that runs in an orderly manner.Chemical science · 2020Article
- Programmable mismatch-fueled high-efficiency DNA signal converter.Chemical science · 2020Article
- DNA nanotechnology approaches for microRNA detection and diagnosis.Nucleic acids research · 2019Review
- A smart fluorescent biosensor for the highly sensitive detection of BRCA1 based on a 3D DNA walker and ESDR cascade amplification.RSC advances · 2019Article
- Linear-hairpin variable primer RT-qPCR for MicroRNA.Chemical science · 2019Article
- An enzyme-free molecular catalytic device: dynamically self-assembled DNA dendrimers forChemical science · 2019Article
- An all-in-one homogeneous DNA walking nanomachine and its application for intracellular analysis of miRNA.Theranostics · 2019Article
- Two-Color-Based Nanoflares for Multiplexed MicroRNAs Imaging in Live Cells.Nanotheranostics · 2018Article
- RNA splicing process analysis for identifying antisense oligonucleotide inhibitors with padlock probe-based isothermal amplification.Chemical science · 2017Article
- Self-assembly of nucleic acid molecular aggregates catalyzed by a triple-helix probe for miRNA detection and single cell imaging.Chemical science · 2016Article
- Two-color imaging of microRNA with enzyme-free signal amplificationChemical science · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Artificial DNA motifs as architectural scaffolds have been widely used to assemble a variety of nanoscale devices. Synthetic DNA nanostructures have accomplished mechanical switching in response to external stimuli, suggesting the promise of constructing a walking device that is being used in the field of biosensors. Here, we design a novel miRNA-responsive DNA walker biosensor based on strand displacement cascades and an enzymatic recycling cleavage strategy. By using miRNA as a driving force, the DNA walkers can be activated to move along the track and generate specific signals for let-7a with a high signal-to-noise ratio. This biosensor exhibits excellent analytical performance toward the sensing of let-7a with great specificity for resolving one nucleotide variation and a detection limit of 58 fM. Such an ultraselective sensor shows that DNA nanostructures have great potential in providing platforms for applications in the fields of biosensing, clinical diagnostics and environmental sample analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.