ArticleChemical science2015
Endogenous signalling control of cell adhesion by using aptamer functionalized biocompatible hydrogel.
Article in Chemical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Hydrogels in cancer treatment: mapping the future of precision drug delivery.Frontiers in immunology · 2025Pooled it
- Functions and applications of enzymes in nucleic acid nanotechnology.Journal of nanobiotechnology · 2025Review
- Branched Polymer Architecture for Modulating Interactions in Material-Bio Interface.Tissue engineering and regenerative medicine · 2025Review
- Advantages of Material Biofunctionalization Using Nucleic Acid Aptamers in Tissue Engineering and Regenerative Medicine.Molecular biotechnology · 2023Review
- Recapitulating dynamic ECM ligand presentation at biomaterial interfaces: Molecular strategies and biomedical prospects.Exploration (Beijing, China) · 2022Review
- Aptamer-Modified Hydrogels.Advances in biochemical engineering/biotechnology · 2021Article
- Traction microscopy with integrated microfluidics: responses of the multi-cellular island to gradients of HGF.Lab on a chip · 2019Article
- Surface Hydrophilicity of Poly(l-Lactide) Acid Polymer Film Changes the Human Adult Adipose Stem Cell Architecture.Polymers · 2018Article
- Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment.Chemical reviews · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Design of biological signal-responsive biomaterials is essential for controlling cell-cell and cell-matrix interactions. Herein, we developed a dynamic hydrogel to control cell adhesion with biological signals in a cellular microenvironment. The basic principle was based on using nucleic acid aptamer to recognize cell signalling and control the display of bioligands on the hydrogel. Not only exogenous signalling but also endogenous signalling secreted by surrounding cells could activate the dynamic scaffold and tune the cell adhesion state. Since diverse aptamers have been developed, our design can be extended to multiple biological inputs. The biochemical signal-responsive system will greatly enhance the understanding of complex biological processes as well as the ability to manipulate cellular behaviors.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.