Evidence map›Paper›PMID 28757959›Full record

ArticleChemical science2015

Photoresponsive immunomagnetic nanocarrier for capture and release of rare circulating tumor cells.

Song-Wei Lv, Jing Wang, Min Xie, Ning-Ning Lu, Zhen Li, Xue-Wei Yan, Si-Liang Cai, Ping-An Zhang, Wei-Guo Dong, Wei-Hua Huang

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 67 citations in OpenAlex.

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  5. [Recent advances in responsive isolation, release and clinical application of circulating tumor cells].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Song-Wei LvKey Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education) , College of Chemistry and Molecular Sciences , Wuhan University , Wuhan 430072 , China . Email: whhuang@whu.edu.cn ; ; Tel: +86-27-68752149.
Jing WangDepartment of Gastroenterology , Renmin Hospital of Wuhan University , Wuhan 430060 , China . Email: dwg@whu.edu.cn.
Min XieKey Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education) , College of Chemistry and Molecular Sciences , Wuhan University , Wuhan 430072 , China . Email: whhuang@whu.edu.cn ; ; Tel: +86-27-68752149.
Ning-Ning LuKey Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education) , College of Chemistry and Molecular Sciences , Wuhan University , Wuhan 430072 , China . Email: whhuang@whu.edu.cn ; ; Tel: +86-27-68752149.
Zhen LiKey Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education) , College of Chemistry and Molecular Sciences , Wuhan University , Wuhan 430072 , China . Email: whhuang@whu.edu.cn ; ; Tel: +86-27-68752149.
Xue-Wei YanKey Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education) , College of Chemistry and Molecular Sciences , Wuhan University , Wuhan 430072 , China . Email: whhuang@whu.edu.cn ; ; Tel: +86-27-68752149.
Si-Liang CaiKey Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education) , College of Chemistry and Molecular Sciences , Wuhan University , Wuhan 430072 , China . Email: whhuang@whu.edu.cn ; ; Tel: +86-27-68752149.
Ping-An ZhangDepartment of Clinical Laboratory , Renmin Hospital of Wuhan University , Wuhan 430060 , China.
Wei-Guo DongDepartment of Gastroenterology , Renmin Hospital of Wuhan University , Wuhan 430060 , China . Email: dwg@whu.edu.cn.
Wei-Hua HuangKey Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education) , College of Chemistry and Molecular Sciences , Wuhan University , Wuhan 430072 , China . Email: whhuang@whu.edu.cn ; ; Tel: +86-27-68752149.
Wuhan University · CNMinistry of Education of the People's Republic of China · CNRenmin Hospital of Wuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Isolation, release and culture of rare circulating tumor cells (CTCs) may, if implemented, promote the progress of individualized anti-tumor therapies. To realize the release of CTCs without disruption of their viability for further culture and analysis, we designed an effective photocontrolled CTC capture/release system by combination of photochemistry and immunomagnetic separation. 7-Aminocoumarin was synthesized as the phototrigger to bridge the connection between the anti-EpCAM antibody and the magnetic beads. The coumarin moieties produced cleavage of a C-O bond under both ultraviolet (UV) and near-infrared (NIR) light illumination, breaking the bridge and releasing CTCs from the immunomagnetic beads. Compared with conventional immunomagnetic separation systems, the negative influence of absorbed immunomagnetic beads on further CTCs culture and analysis was effectively eliminated. The system can specifically recognize 10

Identifiers

PMID28757959
PMCPMC5507187
OpenAlexW1932817457

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.