Evidence map›Paper›PMID 28757888›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2017

San-Yuan Chen, Ru-Hsiou Teng, Meilin Wang, Pei-Lain Chen, Mien-Chun Lin, Cheng-Huang Shen, Chun-Nun Chao, Ming-Ko Chiang, Chiung-Yao Fang, Deching Chang

Open access · hybridAbstract read
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

San-Yuan ChenDepartment of Chinese Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi, Taiwan.
Ru-Hsiou TengInstitute of Molecular Biology, National Chung Cheng University, Chiayi, Taiwan.
Meilin WangDepartment of Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan.
Pei-Lain ChenDepartment of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan.
Mien-Chun LinInstitute of Molecular Biology, National Chung Cheng University, Chiayi, Taiwan.
Cheng-Huang ShenDepartment of Urology, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi, Taiwan.ORCID 0000-0003-0058-5128
Chun-Nun ChaoDepartment of Pediatrics, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi, Taiwan.
Ming-Ko ChiangInstitute of Molecular Biology, National Chung Cheng University, Chiayi, Taiwan.
Chiung-Yao FangDepartment of Medical Research, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi, Taiwan.ORCID 0000-0001-7088-230X
Deching ChangInstitute of Molecular Biology, National Chung Cheng University, Chiayi, Taiwan.ORCID 0000-0003-4097-2560
National Chung Cheng University · TWChia-Yi Christian Hospital · TWCentral Taiwan University of Science and Technology · TWChung Shan Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human polyomaviruses BK (BKPyV) and JC (JCPyV) are ubiquitous pathogens long associated with severe disease in immunocompromised individuals. BKPyV causes polyomavirus-associated nephropathy and hemorrhagic cystitis, whereas JCPyV is the causative agent of the fatal demyelinating disease progressive multifocal leukoencephalopathy. No effective therapies targeting these viruses are currently available. The goal of this study was to identify Chinese medicinal herbs with antiviral activity against BKPyV and JCPyV. We screened extracts of Chinese medicinal herbs for the ability to inhibit hemagglutination by BKPyV and JCPyV virus-like particles (VLPs) and the ability to inhibit BKPyV and JCPyV binding and infection of host cells. Two of the 40 herbal extracts screened,

Identifiers

PMID28757888
PMCPMC5512047
OpenAlexW2727765363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.