Evidence map›Paper›PMID 28757812›Full record

ArticleCalcium binding proteins

Calcium-Dependent Regulation of Ion Channels.

Vikas N Shah, Benjamin Chagot, Walter J Chazin

Open access · greenAbstract read
In one paragraph

Article in Calcium binding proteins. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Calcium Ions in the Physiology and Pathology of the Central Nervous System.International journal of molecular sciences · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Feedback contributions to excitation-contraction coupling in native functioning striated muscle.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. CaThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2020
    Article
  16. Article
  17. Review
  18. The role of calmodulin in regulating calcium-permeable PKD2L1 channel activity.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2019
    Article
  19. GABAThe Journal of physiology · 2019
    Article
  20. S100 calcium binding proteins and ion channels.Frontiers in pharmacology · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Vikas N ShahDepartments of Biochemistry, Chemistry and Physics; Vanderbilt University Medical Center; Nashville, Tennessee USA.
Benjamin ChagotDepartments of Biochemistry, Chemistry and Physics; Vanderbilt University Medical Center; Nashville, Tennessee USA.
Walter J ChazinDepartments of Biochemistry, Chemistry and Physics; Vanderbilt University Medical Center; Nashville, Tennessee USA.
Vanderbilt University Medical Center · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
The Molecular Basis of Local AnesthesiaR01GM056307 · NIGMS · VANDERBILT UNIVERSITY · PI CHAZIN, WALTER J. · 1997 to 2008
$2.6M
S100 PROTEINS: STRUCTURAL BASIS OF FUNCTIONAL PROPERTIESR01GM062112 · NIGMS · VANDERBILT UNIVERSITY · PI CHAZIN, WALTER J. · 2000 to 2009
$2.1M
STRUCTURE AND DYNAMICS OF CA++-BINDING PROTEINS BY NMRR01GM040120 · NIGMS · VANDERBILT UNIVERSITY · PI CHAZIN, WALTER J · 1993 to 2005
$1.5M
NIGMS NIH HHS R01 GM040120NIGMS NIH HHS R01 GM056307NIGMS NIH HHS R01 GM062112NIGMS NIH HHS T32 GM007347
6 · The paper itself

Abstract

Calcium plays an important role in regulating hundreds of biological processes due to its primary role as one of the most ubiquitous second messengers. As a result, the levels of calcium are tightly regulated as are the peak and trough calcium concentrations during a calcium signal. Calcium levels are controlled via a variety of feedback mechanisms and exchangers/transporters. Here the role of calcium in the feedback regulation of ion channel function is reviewed, with an emphasis on the molecular mechanisms governing calcium-dependent function. In particular, the role of calcium in the regulation of voltage-gated sodium, calcium, and potassium channels are reviewed as well as its effects on the ryanodine receptor.

Indexed as

CalciumcalmodulinEF-handion channelsregulation

Identifiers

PMID28757812
PMCPMC5531595
OpenAlexW3025002918

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.