Evidence map›Paper›PMID 28757603›Full record

ReviewNature reviews. Immunology2017

The regulation of immune tolerance by FOXP3.

Ling Lu, Joseph Barbi, Fan Pan

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 331 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
331citing papers in PubMed, 2 pooled it
20.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

331 citing papers in PubMed, 2 syntheses or guidelines pooled it, 559 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. RNA splicing in health and disease.Molecular biomedicine · 2026
    Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Association Between Peripheral IL-2Journal of clinical medicine · 2026
    Article
  13. International journal of molecular sciences · 2026
    Review
  14. Article
  15. Induction of Clinical Operational Tolerance Through Immunosuppression Minimization: Less Is More?Liver international : official journal of the International Association for the Study of the Liver · 2026
    Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article

271 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Ling LuLiver Transplantation Center, First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, China.
Joseph BarbiDepartment of Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA.
Fan PanDepartment of Oncology, Immunology and Hematopoiesis Division, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 401 North Broadway, Baltimore, Maryland 21287, USA.
Nanjing Medical University · CNRoswell Park Comprehensive Cancer Center · USSidney Kimmel Comprehensive Cancer Center · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MARK G FRATTINI · 1985 to 2026
$116.6M
The Role of EOS in Regulatory T-cell Biology.R01AI089830 · NIAID · JOHNS HOPKINS UNIVERSITY · PI PARDOLL, DREW M. · 2010 to 2014
$2.0M
Metabolic regulation of T cell fate and tumor immunityR01AI099300 · NIAID · JOHNS HOPKINS UNIVERSITY · PI PAN, FAN · 2013 to 2017
$2.0M
NCI NIH HHS P30 CA006973NCI NIH HHS P30 CA016056NIAID NIH HHS R01 AI089830NIAID NIH HHS R01 AI099300
6 · The paper itself

Abstract

The proper restraint of the destructive potential of the immune system is essential for maintaining health. Regulatory T (T

Indexed as

Immune ToleranceImmunomodulationAnimalsForkhead Transcription FactorsGene Expression RegulationHumansProtein Processing, Post-TranslationalT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsForkhead Transcription FactorsFOXP3 protein, human

Identifiers

PMID28757603
PMCPMC5793224
OpenAlexW2740495409

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.