ArticleThe Journal of veterinary medical science2017
Diverse distribution of tyrosine receptor kinase B isoforms in rat multiple tissues.
Article in The Journal of veterinary medical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- The neurotoxicity of iodoacetic acid, a byproduct of drinking water disinfection.Frontiers in toxicology · 2025Review
- TrkB phosphorylation in serum extracellular vesicles correlates with cognitive function enhanced by ergothioneine in humans.NPJ science of food · 2024Article
- Autocrine role of senescent cardiac fibroblasts-derived extracellular vesicles.The Journal of veterinary medical science · 2023Article
- Memory-related hippocampal brain-derived neurotrophic factor activation pathways from repetitive transcranial magnetic stimulation in the 3xTg-AD mouse line.Experimental gerontology · 2023Article
- Review
- The Ketogenic Diet Improves Gut-Brain Axis in a Rat Model of Irritable Bowel Syndrome: Impact on 5-HT and BDNF Systems.International journal of molecular sciences · 2022Article
- Feeding and food availability modulate brain-derived neurotrophic factor, an orexigen with metabolic roles in zebrafish.Scientific reports · 2020Article
- Acute intracerebroventricular injection of chemerin-9 increases systemic blood pressure through activating sympathetic nerves via CMKLR1 in brain.Pflugers Archiv : European journal of physiology · 2020Article
- Article
- Optimal Isolation Method of Small Extracellular Vesicles from Rat Plasma.International journal of molecular sciences · 2019Article
- Cathepsin S degrades arresten and canstatin in infarcted area after myocardial infarction in rats.The Journal of veterinary medical science · 2019Article
- Electro-Acupuncture Ameliorated MPTP-Induced Parkinsonism in Mice via TrkB Neurotrophic Signaling.Frontiers in neuroscience · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tyrosine receptor kinase B (TrkB), a receptor for brain-derived neurotrophic factor and neurotrophin-3, includes the alternatively spliced three isoforms specifically in rats. Each isoform, full length TrkB (TrkB FL), truncated TrkB type-1 (TrkB T1) and type-2 (TrkB T2), seems to mediate diverse cellular function. Some studies suggest that TrkB plays a key role in both neural and non-neural systems. In the present study, we examined mRNA and protein expression profile of three TrkB isoforms in normal adult rat multiple tissues. TrkB FL mRNA and protein were both highly expressed exclusively in brain. While TrkB T1 mRNA was highly expressed exclusively in brain, glycosylated TrkB T1 protein was expressed in brain and heart. TrkB T2 mRNA level in brain was the highest. In brain, TrkB FL mRNA expression was higher in cerebral cortex, but lower in brainstem. TrkB T1 mRNA expression was higher in hypothalamus, but lower in cerebellum. TrkB T2 mRNA expression was higher in cerebral cortex and cerebellum, but lower in brainstem. The present study for the first time clarified diverse distribution of three TrkB isoforms in rat multiple tissues and could serve as a useful resource for understanding the physiology and pathophysiology of mammals including human via comparing the expression pattern of TrkB isoforms.
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