ArticleFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2017
Permethrin alters glucose metabolism in conjunction with high fat diet by potentiating insulin resistance and decreases voluntary activities in female C57BL/6J mice.
Article in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 44 citations in OpenAlex.
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- Hawthorn leaf and its extract alleviate high-fat diet-induced obesity and modulate gut microbiome in mice.Current research in food science · 2025Article
- Prenatal exposure to insecticides and child cardiometabolic risk factors in the VHEMBE birth cohort.Environmental epidemiology (Philadelphia, Pa.) · 2022Article
- Longitudinal Study of Metabolic Biomarkers among Conventional and Organic Farmers in Thailand.International journal of environmental research and public health · 2020Article
- Perfluorobutanesulfonic Acid (PFBS) Induces Fat Accumulation in HepG2 Human Hepatoma.Toxicological and environmental chemistry · 2020Article
- Permethrin and ivermectin modulate lipid metabolism in steatosis-induced HepG2 hepatocyte.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2019Article
- Permethrin, a pyrethroid insecticide, regulates ERK1/2 activation through membrane depolarization-mediated pathway in HepG2 hepatocytes.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2018Article
- Perfluorobutanesulfonic acid (PFBS) potentiates adipogenesis of 3T3-L1 adipocytes.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2018Article
- Exposure to permethrin promotes high fat diet-induced weight gain and insulin resistance in male C57BL/6J mice.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2018Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Permethrin, a type 1 pyrethroid insecticide, was previously reported to promote adipogenesis in 3T3-L1 adipocytes and insulin resistance in C2C12 muscle cells; however, the effects of permethrin exposure on glucose and lipid metabolisms in vivo remain unknown. The purpose of this study was to investigate the effects of permethrin exposure on glucose and lipid homeostasis as well as voluntary movement in female mice in response to dietary fat. We tested three doses of permethrin (50, 500, & 5000 μg/kg body weight/day) in low fat diet-fed (4% w/w of diet) and high fat diet-fed (20% w/w of diet) female C57BL/6 J mice for twelve weeks. Our results demonstrated that permethrin treatment potentiated high fat diet-induced insulin resistance as indicated by insulin tolerance tests, glucose tolerance tests, and homeostasis model assessment - insulin resistance (HOMA-IR) without altering weight or fat mass. Permethrin treatment significantly decreased voluntary movement and elevated blood glucose and insulin levels. Western blot results further showed that permethrin impaired insulin signaling via the Akt signaling pathway in the gastrocnemius muscle. Taken together, these results suggest that oral administration of permethrin potentiated high fat diet-induced insulin resistance, possibly increasing the risk of type 2 diabetes without altering weight gain in female C57BL/6 J mice.
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