ArticleThe journal of allergy and clinical immunology. In practice
Distinct Asthma Phenotypes Among Older Adults with Asthma.
Article in The journal of allergy and clinical immunology. In practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The impact of patient autonomy on older adults with asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2018Trial
- PP4 deficiency drives airway epithelial senescence via the PERK-eIF2α-ATF4-p21 axis in severe asthma.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Differences in the efficacies of commonly used asthma questionnaires for predicting asthma-related outcomes among elderly and non-elderly patients in Japan.The World Allergy Organization journal · 2025Article
- The Associations of Anaemia Status and Body Mass Index with Asthma Severity in Saudi Arabia: A Comparative Study.Journal of asthma and allergy · 2025Article
- Identification of biologic-responsive phenotypes in elderly people with eosinophilic asthma.The journal of allergy and clinical immunology. Global · 2024Article
- Review
- Phenotyping older adults with asthma by means of cluster analysis.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022Article
- Asthma clustering methods: a literature-informed application to the children's health study data.The Journal of asthma : official journal of the Association for the Care of Asthma · 2022Review
- Depressive Symptoms and Overperception of Airflow Obstruction in Older Adults With Asthma.Psychosomatic medicine · 2021Article
- A Systematic Review of Asthma Phenotypes Derived by Data-Driven Methods.Diagnostics (Basel, Switzerland) · 2021Review
- Differences in the Clinical Characteristics of Early- and Late-Onset Asthma in Elderly Patients.BioMed research international · 2020Article
- Association Between Epithelial Cytokines and Clinical Phenotypes of Elderly Asthma.Allergy, asthma & immunology research · 2019Article
- Hormones, sex, and asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2018Review
- Asthma Over the Age of 65: All's Well That Ends Well.The journal of allergy and clinical immunology. In practiceReview
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6 authors.
Funding
Abstract
backgroundOlder adults have high rates of asthma morbidity and mortality. Asthma is now recognized as a heterogeneous disease, yet the distinct phenotypes among older adults are unknown.
objectiveThe objective of this study was to identify asthma phenotypes in a diverse population of elderly patients with asthma.
methodsUsing cluster analysis, 180 older adults with persistent asthma were analyzed. Subjects completed detailed questionnaires, skin prick testing, and spirometry with reversibility. Twenty-four core variables were analyzed.
resultsFour groups were identified. Subjects in cluster 1 (n = 69) typically had asthma diagnosed after the age of 40 and the shortest duration of asthma. Cluster 2 (n = 40) had the mildest asthma defined by spirometry, Asthma Control test (ACT), and Asthma Quality of Life Questionnaire (AQLQ). They also had the lowest body mass index (BMI), lowest depression score, and least number of comorbidities. Cluster 3 (n = 46) had the longest duration of asthma (56 years) and the highest atopic skin test sensitization (74%). Cluster 4 (n = 25) had the most severe asthma, with extremely low FEV
conclusionsIn older adults with asthma, distinct phenotypes vary on key features that are more pronounced among the elderly, including comorbidities, fixed airway obstruction, and duration of asthma ≥40 years. Further work is required to determine the clinical and therapeutic implications for different asthma phenotypes in older adults.
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