Evidence map›Paper›PMID 28757309›Full record

ArticlePediatric neurology2017

Reliability and Clinical Correlation of Transcranial Doppler Ultrasound in Sturge-Weber Syndrome.

Elizabeth A Offermann, Aditya Sreenivasan, M Robert DeJong, Doris D M Lin, Charles E McCulloch, Melissa G Chung, Anne M Comi, National Institute of Health Sponsor, Rare Disease Clinical Research Consortium (RDCRN), Brain and Vascular Malformation Consortium (BVMC) and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Elizabeth A OffermannDepartment of Neurology Medicine, Kennedy Krieger Institute, Baltimore, Maryland.
Aditya SreenivasanDepartment of Neurology Medicine, Kennedy Krieger Institute, Baltimore, Maryland.
M Robert DeJongDepartment of Radiology and Radiological Science, Johns School of Medicine, Baltimore, Maryland.
Doris D M LinDepartment of Radiology and Radiological Science, Johns School of Medicine, Baltimore, Maryland.
Charles E McCullochDepartment of Epidemiology and Biostatistics, University of California, San Francisco, California.
Melissa G ChungDivisions of Neurology and Critical Care Medicine, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio.
Anne M ComiDepartment of Neurology Medicine, Kennedy Krieger Institute, Baltimore, Maryland; Department of Neurology, Johns School of Medicine, Baltimore, Maryland; Department of Pediatrics, Johns School of Medicine, Baltimore, Maryland. Electronic address: comi@kennedykrieger.org.
National Institute of Health Sponsor
Rare Disease Clinical Research Consortium (RDCRN)
Brain and Vascular Malformation Consortium (BVMC)
National Sturge-Weber Syndrome Workgroup
Johns Hopkins University · USKennedy Krieger Institute · USUniversity of California, San Francisco · USThe Ohio State University · US

Funding

VCRC Administration UnitU54NS065705 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KIM, HELEN · 2009 to 2023
$20.8M
NINDS NIH HHS U54 NS065705
6 · The paper itself

Abstract

backgroundThe reproducibility of transcranial Doppler (TCD) ultrasound measurements in Sturge-Weber syndrome (SWS) and TCD's ability to predict neurological progression is unknown.

methodsIn 14 individuals with SWS, TCD measured mean flow velocity, pulsatility index, peak systolic velocity, and end-diastolic velocity in the middle, posterior, and anterior cerebral arteries of the affected and unaffected hemisphere. TCD was performed either once (n = 5) or twice in one day (n = 9). We assessed the reproducibility of the measurements performed twice on the same day on subjects and compared the TCD measurements to previously published age-matched controls. Clinically obtained neuroimaging was scored for extent and severity of SWS brain involvement. Patients were prospectively assigned SWS neuroscores.

resultsMiddle cerebral artery velocity (r = 0.79, P = 0.04, n = 7), posterior cerebral artery velocity (r = 0.90, P = 0.04, n = 5), and anterior cerebral artery pulsatility index (r = 0.82, P = 0.02, n = 7) were reproducible TCD measurements comparing same-day percent side-to-side differences. In subjects with SWS, affected and unaffected mean peak systolic velocity and end-diastolic velocity in the middle, posterior, and anterior cerebral arteries were globally lower compared with age-matched control subjects. Subjects with the lowest affected middle cerebral artery velocity had the greatest worsening in the total neurological score between time 1 and 2 (r = -0.73, P = 0.04, n = 8) and the most severe magnetic resonance imaging involvement of the affected frontal lobe (r = -0.82, P = 0.007, n = 9).

conclusionsTCD may be a reliable measure with potential clinical value, indicating that blood flow may be globally decreased in SWS patients with unilateral brain involvement.

Indexed as

Statistics as TopicAdolescentBrainCerebrovascular CirculationChildChild, PreschoolFemaleHemodynamicsHumansInfantMagnetic Resonance ImagingMaleMiddle Cerebral ArteryPerceptual DisordersPulsatile FlowReproducibility of Resultsend-diastolic velocitypeak systolic velocitySturge-Weber syndrometranscranial Doppler ultrasound

Identifiers

PMID28757309
PMCPMC5977390
OpenAlexW2613253566

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.