ArticleOsteoarthritis and cartilage2017
Gout and risk of knee replacement for severe knee osteoarthritis in the Singapore Chinese Health Study.
Article in Osteoarthritis and cartilage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 25 citations in OpenAlex.
- Relation of Colchicine to Total Joint Arthroplasty Among People With Gout in a Population-Based Cohort Study.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Circulating Metabolic Factors Mediating the Effect of Obesity-Related Indicators on Meniscal Injuries: A Mendelian Randomization Study.International journal of genomics · 2026Article
- The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms.Frontiers in endocrinology · 2025Review
- Associations of Changes in Knee Hyaline Cartilage Composition Measured With Dual-Energy Computed Tomography in Gout, Aging and Osteoarthritis.Cartilage · 2024Article
- Advanced Erosive Gouty Arthropathy of the Knee.Cureus · 2024Article
- The Evolving Landscape of Gout in the Female: A Narrative Review.Gout, urate, and crystal deposition disease · 2023Article
- Developing prediction models for total knee replacement surgery in patients with osteoarthritis: Statistical analysis plan.Osteoarthritis and cartilage open · 2020Article
- The efficacy and tolerability of febuxostat treatment in a cohort of Chinese Han population with history of gout.The Journal of international medical research · 2020Article
- Urate and osteoarthritis: Evidence for a reciprocal relationship.Joint bone spine · 2019Review
- The association between asymptomatic hyperuricemia and knee osteoarthritis: data from the third National Health and Nutrition Examination Survey.Osteoarthritis and cartilage · 2019Article
- Gout and healthcare utilization and complications after hip arthroplasty: a cohort study using the US National Inpatient Sample (NIS).Clinical rheumatology · 2019Article
- Crystal arthritis: Crystallizing our ideas about gout and osteoarthritis.Nature reviews. Rheumatology · 2017Article
- Exploring the Link between Uric Acid and Osteoarthritis.Frontiers in medicine · 2017Review
- Consistency of the Sonographic Image (Double Contour Sign) in Patients with Gout after Ambulation.Journal of medical ultrasoundArticle
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveWhile cross-sectional and retrospective case-control studies suggest that gout is associated with knee osteoarthritis (KOA), no prospective study has evaluated the risk of total knee replacement (TKR) for KOA in association with gout. We prospectively evaluated the association between gout and the risk of TKR due to severe KOA.
designWe used data from the Singapore Chinese Health Study (SCHS), a prospective cohort with 63,257 Chinese adults aged 45-74 years at recruitment (1993-1998). Self-report of physician-diagnosed gout was enquired at follow-up I interview (1999-2004) from 52,322 subjects. TKR cases for KOA after follow-up I were identified via linkage with nationwide hospital discharge database through 31 December 2011. Multivariable Cox proportional hazards regression model was applied with adjustment for potential risk factors of KOA.
resultsAmong 51,858 subjects (22,180 men and 29,678 women) included in this analysis, after average 9.7 follow-up years, there were 1,435 cases of TKR. Gout was associated with 39% higher risk of TKR in women [hazard ratio (HR) 1.39; 95% confidence interval (CI) 1.08-1.79] but not in men (HR 0.78; 95% CI 0.49-1.23). The positive gout-TKR association in women remained after excluding participants with self-reported history of arthritis (HR 1.57; 95% CI 1.04-2.37). This association was stronger in women who were lean (body mass index [BMI] < 23 kg/m
conclusionGout is associated with risk of severe KOA, especially in lean women, suggesting the crystal arthritis may play a role in the pathogenesis or progression of OA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.