ArticleBiological psychiatry2017
Converging Prefronto-Insula-Amygdala Pathways in Negative Emotion Regulation in Marmoset Monkeys.
Article in Biological psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- A unifying account of loss aversion and loneliness: from neurocognitive bases to affective dysfunction.Frontiers in psychology · 2026Article
- Topographic organisation of the claustrum-amygdala-prefrontal circuitry in the common marmoset (Callithrix jacchus).Brain structure & function · 2025Article
- Distinct neural computations scale the violation of expected reward and emotion in social transgressions.Communications biology · 2025Article
- The positive and negative emotion functions related to loneliness: a systematic review of behavioural and neuroimaging studies.Psychoradiology · 2023Review
- Prefrontal influences on the function of the neural circuitry underlying anxious temperament in primates.Oxford open neuroscience · 2023Article
- Individual variation in white matter microstructure is related to better recovery from negative stimuli.Emotion (Washington, D.C.) · 2022Article
- Ultrasound modulation of macaque prefrontal cortex selectively alters credit assignment-related activity and behavior.Science advances · 2021Article
- Combining brain perturbation and neuroimaging in non-human primates.NeuroImage · 2021Review
- Cerebral blood flow in 5- to 8-month-olds: Regional tissue maturity is associated with infant affect.Developmental science · 2020Article
- Expected value and sensitivity to punishment modulate insular cortex activity during risky decision making.Scientific reports · 2020Article
- Trait Anxiety Mediated by Amygdala Serotonin Transporter in the Common Marmoset.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Anger Inhibition and Pain Modulation.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2019Article
- The central extended amygdala in fear and anxiety: Closing the gap between mechanistic and neuroimaging research.Neuroscience letters · 2019Review
- Disturbed effective connectivity patterns in an intrinsic triple network model are associated with posttraumatic stress disorder.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- Cyto- and Myelo-Architecture of the Amygdaloid Complex of the Common Marmoset Monkey (Frontiers in neuroanatomy · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundImpaired regulation of emotional responses to potential threat is a core feature of affective disorders. However, while the subcortical circuitry responsible for processing and expression of fear has been well characterized, the top-down control of this circuitry is less well understood. Our recent studies demonstrated that heightened emotionality, as measured both physiologically and behaviorally, during conditioned fear and innate/social threat was induced, independently, by excitotoxic lesions of either the anterior orbitofrontal cortex (antOFC) or ventrolateral prefrontal cortex (vlPFC). An important outstanding question is whether the antOFC and vlPFC act on common or distinct downstream targets to regulate negative emotion.
methodsThe question was addressed by combining localized excitotoxic lesions in the PFC of a nonhuman primate and functional neuroimaging ([
results[
conclusionsThese findings demonstrate that the distinct control functions of the antOFC and vlPFC converge on the same downstream targets to promote emotion regulation, taking us closer to a mechanistic understanding of different forms of anxiety.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.