ArticleBMC biology2017
The house spider genome reveals an ancient whole-genome duplication during arachnid evolution.
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Article in BMC biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 178 papers.
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178citing papers in PubMed
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178 citing papers in PubMed, 484 citations in OpenAlex.
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- Assessment of the Effects of Electromagnetic Fields on Apoptosis and Stress Protein Biomarkers in the SpiderInternational journal of molecular sciences · 2026Article
- Spider peptides from Brachypelma smithi with slightly different amino acids at their C-terminal loops exert different insecticidal activities.Amino acids · 2026Article
- Conserved and diverged embryonic expression patterns of panarthropod NK-Cluster genes and new evidence for CRE-shuffling.BMC ecology and evolution · 2026Article
- Big Spider, Big Genome: Chromosome-Level Genome of a North American Tarantula (Aphonopelma marxi) and Comparative Genomics Across 300 Million Years of Spider Evolution.Genome biology and evolution · 2026Article
- Ancient gene linkages and ultraconserved elements disentangle Acari interrelationships.iScience · 2026Article
- Developmental system drift in the patterning of the arthropod tarsus.Proceedings. Biological sciences · 2026Article
- Exploring the First Draft Genome of the Oribatid Mite, Oppia nitens: A Standardized Model Invertebrate in Soil Ecotoxicology.Genome biology and evolution · 2026Article
- An ancient genome duplication event drives the development and evolution of spinnerets in spiders.Science advances · 2026Article
- The repetitive genome of the Ixodes ricinus tick reveals transposable elements have driven genome evolution in ticks.Genome biology · 2026Article
- ERGA-CBP chromosome-level genome assembly of the blind scorpionOpen research Europe · 2026Article
- From candidate genes to omics: Unbiased approaches reshaping arthropod Evo-Devo.Genetics and molecular biology · 2026Article
- Molecular Mechanisms of Venom Diversity.Toxins · 2025Review
- Assessing the Impact of Whole Genome Duplication on Gene Expression and Regulation During Arachnid Development.Genome biology and evolution · 2025Article
- A newly evolved small secretory peptide enhances mechanical properties of spider silk.Nature communications · 2025Article
- Genome Architecture and Speciation in Plants and Animals.Molecular ecology · 2025Review
- Gene and Genome Duplication in Spiders.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Review
- Arthropod Pax Gene Evolution: A Role for Vanessa Cardui Twin of Eyeless in Eye Development.Molecular biology and evolution · 2025Article
- The genome of a sea spider corroborates a shared Hox cluster motif in arthropods with a reduced posterior tagma.BMC biology · 2025Article
118 more citing papers are in PubMed but not listed here.
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Authors and funding
55 authors at 20 institutions in 9 countries.
Evelyn E SchwagerDepartment of Biological and Medical Sciences, Oxford Brookes University, Gipsy Lane, Oxford, OX3 0BP, UK.
Prashant P SharmaDepartment of Zoology, University of Wisconsin-Madison, 430 Lincoln Drive, Madison, WI, 53706, USA.
Thomas ClarkeDepartment of Biology, Washington and Lee University, 204 West Washington Street, Lexington, VA, 24450, USA.
Daniel J LeiteDepartment of Biological and Medical Sciences, Oxford Brookes University, Gipsy Lane, Oxford, OX3 0BP, UK.
Torsten WierschinErnst Moritz Arndt University Greifswald, Institute for Mathematics and Computer Science, Walther-Rathenau-Str. 47, 17487, Greifswald, Germany.
Matthias PechmannDepartment for Developmental Biology, University Goettingen, Johann-Friedrich-Blumenbach-Institut for Zoology and Anthropology, GZMB Ernst-Caspari-Haus, Justus-von-Liebig-Weg 11, 37077, Goettingen, Germany.
Yasuko Akiyama-OdaJT Biohistory Research Hall, 1-1 Murasaki-cho, Takatsuki, Osaka, 569-1125, Japan.
Lauren EspositoInstitute for Biodiversity Science and Sustainability, California Academy of Sciences, 55 Music Concourse Drive, San Francisco, CA, 94118, USA.
Jesper BechsgaardDepartment of Bioscience, Aarhus University, Ny Munkegade 116, building 1540, 8000, Aarhus C, Denmark.
Trine BildeDepartment of Bioscience, Aarhus University, Ny Munkegade 116, building 1540, 8000, Aarhus C, Denmark.
Alexandra D BuffryDepartment of Biological and Medical Sciences, Oxford Brookes University, Gipsy Lane, Oxford, OX3 0BP, UK.
Hsu ChaoHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
Huyen DinhHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
HarshaVardhan DoddapaneniHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
Shannon DuganHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
Cornelius EibnerDepartment of Genetics, Friedrich-Schiller-University Jena, Philosophenweg 12, 07743, Jena, Germany.
Cassandra G ExtavourDepartment of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA, 02138, USA.
Peter FunchDepartment of Bioscience, Aarhus University, Ny Munkegade 116, building 1540, 8000, Aarhus C, Denmark.
Jessica GarbDepartment of Biological Sciences, University of Massachusetts Lowell, 198 Riverside Street, Lowell, MA, 01854, USA.
Luis B GonzalezDepartment of Biological and Medical Sciences, Oxford Brookes University, Gipsy Lane, Oxford, OX3 0BP, UK.
Vanessa L GonzalezSmithsonian National Museum of Natural History, MRC-163, P.O. Box 37012, Washington, DC, 20013-7012, USA.
Sam Griffiths-JonesFaculty of Biology Medicine and Health, University of Manchester, D.1416 Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK.
Yi HanHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
Cheryl HayashiDepartment of Biology, University of California, Riverside, Riverside, CA, 92521, USA.
Maarten HilbrantDepartment of Biological and Medical Sciences, Oxford Brookes University, Gipsy Lane, Oxford, OX3 0BP, UK.
Daniel S T HughesHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
Ralf JanssenDepartment of Earth Sciences, Palaeobiology, Uppsala University, Villavägen 16, 75236, Uppsala, Sweden.
Sandra L LeeHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
Ignacio MaesoCentro Andaluz de Biología del Desarrollo (CABD), Consejo Superior de Investigaciones Científicas/Universidad Pablo de Olavide, Sevilla, Spain.
Shwetha C MuraliHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
Donna M MuznyHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
Rodrigo Nunes da FonsecaNucleo em Ecologia e Desenvolvimento SocioAmbiental de Macaé (NUPEM), Campus Macaé, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, 27941-222, Brazil.
Christian L B PaeseDepartment of Biological and Medical Sciences, Oxford Brookes University, Gipsy Lane, Oxford, OX3 0BP, UK.
Jiaxin QuHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
Matthew RonshaugenFaculty of Biology Medicine and Health, University of Manchester, D.1416 Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK.
Christoph SchomburgDepartment for Developmental Biology, University Goettingen, Johann-Friedrich-Blumenbach-Institut for Zoology and Anthropology, GZMB Ernst-Caspari-Haus, Justus-von-Liebig-Weg 11, 37077, Goettingen, Germany.
Anna SchönauerDepartment of Biological and Medical Sciences, Oxford Brookes University, Gipsy Lane, Oxford, OX3 0BP, UK.
Angelika StollewerkSchool of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, E1 4NS, London, UK.
Montserrat Torres-OlivaDepartment for Developmental Biology, University Goettingen, Johann-Friedrich-Blumenbach-Institut for Zoology and Anthropology, GZMB Ernst-Caspari-Haus, Justus-von-Liebig-Weg 11, 37077, Goettingen, Germany.
Natascha TuretzekDepartment for Developmental Biology, University Goettingen, Johann-Friedrich-Blumenbach-Institut for Zoology and Anthropology, GZMB Ernst-Caspari-Haus, Justus-von-Liebig-Weg 11, 37077, Goettingen, Germany.
Bram VanthournoutDepartment of Bioscience, Aarhus University, Ny Munkegade 116, building 1540, 8000, Aarhus C, Denmark.
John H WerrenBiology Department, University of Rochester, Rochester, NY, 14627, USA.
Carsten WolffHumboldt-Universität of Berlin, Institut für Biologie, Philippstr.13, 10115, Berlin, Germany.
Kim C WorleyHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
Gregor BucherDepartment of Evolutionary Developmental Genetics, Johann-Friedrich-Blumenbach-Institute, GZMB, Georg-August-University, Göttingen Campus, Justus von Liebig Weg 11, 37077, Göttingen, Germany. gbucher1@gwdg.de.
Richard A GibbsHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA. agibbs@bcm.edu.
Jonathan CoddingtonSmithsonian National Museum of Natural History, MRC-163, P.O. Box 37012, Washington, DC, 20013-7012, USA. coddington@si.edu.
Hiroki OdaJT Biohistory Research Hall, 1-1 Murasaki-cho, Takatsuki, Osaka, 569-1125, Japan. hoda@brh.co.jp.
Mario StankeErnst Moritz Arndt University Greifswald, Institute for Mathematics and Computer Science, Walther-Rathenau-Str. 47, 17487, Greifswald, Germany. mario.stanke@uni-greifswald.de.
Nadia A AyoubDepartment of Biology, Washington and Lee University, 204 West Washington Street, Lexington, VA, 24450, USA. ayoubn@wlu.edu.
Nikola-Michael PrpicDepartment for Developmental Biology, University Goettingen, Johann-Friedrich-Blumenbach-Institut for Zoology and Anthropology, GZMB Ernst-Caspari-Haus, Justus-von-Liebig-Weg 11, 37077, Goettingen, Germany. nprpic@uni-goettingen.de.
Jean-François FlotUniversité libre de Bruxelles (ULB), Evolutionary Biology & Ecology, C.P. 160/12, Avenue F.D. Roosevelt 50, 1050, Brussels, Belgium. jflot@ulb.ac.be.
Nico PosnienDepartment for Developmental Biology, University Goettingen, Johann-Friedrich-Blumenbach-Institut for Zoology and Anthropology, GZMB Ernst-Caspari-Haus, Justus-von-Liebig-Weg 11, 37077, Goettingen, Germany. nico.posnien@biologie.uni-goettingen.de.
Stephen RichardsHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA. stephenr@bcm.edu.
Alistair P McGregorDepartment of Biological and Medical Sciences, Oxford Brookes University, Gipsy Lane, Oxford, OX3 0BP, UK. amcgregor@brookes.ac.uk.
Baylor College of Medicine · USOxford Brookes University · GBBaylor Genetics · USAarhus University · DKNational Museum of Natural History · USUniversität Greifswald · DEUniversity of Manchester · GBWashington and Lee University · USCalifornia Academy of Sciences · USConsejo Superior de Investigaciones Científicas · ESFriedrich Schiller University Jena · DEHarvard University · USHumboldt-Universität zu Berlin · DEOsaka Medical and Pharmaceutical University · JPOsaka University · JPQueen Mary University of London · GBUniversidade Federal do Rio de Janeiro · BRUniversité Libre de Bruxelles · BEUniversity of California, Riverside · USUniversity of Cologne · DE
Funding
The Human Genome Sequencing CenterU54HG003273 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2004 to 2015
$341.3MNHGRI NIH HHS U54 HG003273
Abstract
backgroundThe duplication of genes can occur through various mechanisms and is thought to make a major contribution to the evolutionary diversification of organisms. There is increasing evidence for a large-scale duplication of genes in some chelicerate lineages including two rounds of whole genome duplication (WGD) in horseshoe crabs. To investigate this further, we sequenced and analyzed the genome of the common house spider Parasteatoda tepidariorum.
resultsWe found pervasive duplication of both coding and non-coding genes in this spider, including two clusters of Hox genes. Analysis of synteny conservation across the P. tepidariorum genome suggests that there has been an ancient WGD in spiders. Comparison with the genomes of other chelicerates, including that of the newly sequenced bark scorpion Centruroides sculpturatus, suggests that this event occurred in the common ancestor of spiders and scorpions, and is probably independent of the WGDs in horseshoe crabs. Furthermore, characterization of the sequence and expression of the Hox paralogs in P. tepidariorum suggests that many have been subject to neo-functionalization and/or sub-functionalization since their duplication.
conclusionsOur results reveal that spiders and scorpions are likely the descendants of a polyploid ancestor that lived more than 450 MYA. Given the extensive morphological diversity and ecological adaptations found among these animals, rivaling those of vertebrates, our study of the ancient WGD event in Arachnopulmonata provides a new comparative platform to explore common and divergent evolutionary outcomes of polyploidization events across eukaryotes.
Indexed as
Evolution, MolecularGene DuplicationGenomeAnimalsFemaleMaleSpidersSyntenyCentruroides sculpturatusEvolutionGene duplicationGenomeHox genesParasteatoda tepidariorum
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