Evidence map›Paper›PMID 28756589›Full record

ArticleNeurosurgical review2018

Crosstalk between the angiotensin and endothelin system in the cerebrovasculature after experimental induced subarachnoid hemorrhage.

Stefan Wanderer, Jan Mrosek, Hartmut Vatter, Volker Seifert, Juergen Konczalla

Abstract read
PubMed Publisher
In one paragraph

Article in Neurosurgical review, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  4. Article
  5. Article
  6. Review
  7. Brain Vasculature and Cognition.Arteriosclerosis, thrombosis, and vascular biology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Stefan WandererDepartment of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland. stefan.wanderer@ksa.ch.ORCID http://orcid.org/0000-0002-4510-5741
Jan MrosekDepartment of Neurosurgery, Goethe-University Hospital, Frankfurt am Main, Germany.
Hartmut VatterDepartment of Neurosurgery, Rheinische Friedrich-Wilhelms-University, Bonn, Germany.
Volker SeifertDepartment of Neurosurgery, Goethe-University Hospital, Frankfurt am Main, Germany.
Juergen KonczallaDepartment of Neurosurgery, Goethe-University Hospital, Frankfurt am Main, Germany.
Goethe University Frankfurt · DEKantonsspital Aarau · CHUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Under physiologic conditions, losartan showed a dose-dependent antagonistic effect to the endothelin-1 (ET-1)-mediated vasoconstriction. This reduced vasoconstriction was abolished after preincubation with an endothelin B

Indexed as

Angiotensin II Type 1 Receptor BlockersAngiotensinsAnimalsBasilar ArteryDisease Models, AnimalEndothelin-1Endothelin Receptor AntagonistsLosartanMaleOligopeptidesPeptides, CyclicPiperidinesRatsRats, Sprague-DawleyReceptor Cross-TalkSubarachnoid HemorrhageAngiotensin II Type 1 Receptor BlockersAngiotensinsBQ 788cyclo(Trp-Asp-Pro-Val-Leu)Endothelin-1Endothelin Receptor AntagonistsLosartanOligopeptidesPeptides, CyclicPiperidinesAngiotensinAT1-receptorCerebrovasculatureCrosstalkEndothelinET(A)-receptorET(B1)-receptorLosartanSubarachnoid hemorrhage

Identifiers

PMID28756589
OpenAlexW2741227993

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.