Evidence map›Paper›PMID 28756486›Full record

ArticleBrain structure & function2018

Cortical morphology of the pars opercularis and its relationship to motor-inhibitory performance in a longitudinal, developing cohort.

Lauren B Curley, Erik Newman, Wesley K Thompson, Timothy T Brown, Donald J Hagler, Natacha Akshoomoff, Chase Reuter, Anders M Dale, Terry L Jernigan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain structure & function, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Lauren B CurleyDepartment of Cognitive Science, University of California, San Diego, La Jolla, USA.
Erik NewmanCenter for Human Development, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0115, USA.
Wesley K ThompsonCenter for Human Development, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0115, USA.
Timothy T BrownCenter for Human Development, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0115, USA.
Donald J HaglerCenter for Multimodal Imaging and Genetics, University of California, San Diego School of Medicine, La Jolla, USA.
Natacha AkshoomoffCenter for Human Development, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0115, USA.
Chase ReuterDepartment of Psychiatry, University of California, San Diego School of Medicine, La Jolla, USA.
Anders M DaleDepartment of Cognitive Science, University of California, San Diego, La Jolla, USA.
Terry L JerniganDepartment of Cognitive Science, University of California, San Diego, La Jolla, USA. tjernigan@ucsd.edu.
University of California, San Diego · US

Funding

Creating a Pediatric Imaging-Genomics Data ResourceRC2DA029475 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, LINDA, DALE, ANDERS M · 2009 to 2011
$9.1M
Mapping Individual Cognitive Differences to Neural Variance and School ReadinessR01HD061414 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JERNIGAN, TERRY L. · 2010 to 2014
$3.3M
Neurobehavioral Contributors to Math Failure: A Reward-Based Learning FrameworkR24HD075489 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JERNIGAN, TERRY L. · 2012 to 2015
$2.2M
National Institute of Child Health and Human Development R01HD061414National Institute of Child Health and Human Development R24HD075489National Institute of Child Health and Human Development RC2DA029475NICHD NIH HHS R01 HD061414NICHD NIH HHS R24 HD075489NIDA NIH HHS RC2 DA029475
6 · The paper itself

Abstract

This study investigates the relationship between variability in cortical surface area and thickness of the pars opercularis of the inferior frontal gyrus and motor-inhibitory performance on a stop-signal task in a longitudinal, typically developing cohort of children and adolescents. Linear mixed-effects models were used to investigate the hypotheses that (1) cortical thinning and (2) a relatively larger cortical surface area of the bilateral pars opercularis of the inferior frontal gyrus would predict better performance on the stop-signal task in a cohort of 110 children and adolescents 4-13 years of age, with one to four observations (totaling 232 observations). Cortical thickness of the bilateral opercular region was not related to inhibitory performance. However, independent of age, gender, and total cortical surface area, relatively larger cortical surface area of the bilateral opercular region of the inferior frontal gyrus was associated with better motor-inhibitory performance. Follow-up analyses showed a significant effect of surface area of the right pars opercularis, but no evidence for an effect of area of left pars opercularis, on motor-inhibitory performance. These findings are consistent with the previous work in adults showing that cortical morphology of the pars opercularis is related to inhibitory functioning. It also expands upon this literature by showing that, in contrast to earlier work highlighting the importance of cortical thickness of this region in adults, relative cortical surface area of the pars opercularis may be related to developing motor-inhibitory functions during childhood and adolescence. Relationships between cortical phenotypes and individual differences in behavioral measures may vary across the lifespan.

Indexed as

Brain MappingInhibition, PsychologicalAdolescentBroca AreaChildCohort StudiesFemaleFunctional LateralityHumansImage Processing, Computer-AssistedMaleMotor ActivityNeuroimagingReaction TimeSignal Detection, PsychologicalBrain developmentCortical surface areaCortical thicknessInferior frontal gyrusMagnetic resonance imagingMotor inhibition

Identifiers

PMID28756486
PMCPMC5772141
OpenAlexW2741354405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.