ArticlePediatric nephrology (Berlin, Germany)2017
Urine neutrophil gelatinase-associated lipocalin and other biomarkers in infants with urinary tract infection and in febrile controls.
Article in Pediatric nephrology (Berlin, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Evaluation of diagnostic accuracy of urine neutrophil gelatinase-associated lipocalin in patients with symptoms of urinary tract infections: a meta-analysis.Frontiers in pediatrics · 2024Pooled it
- Accuracy of NGAL as a Biomarker for Urinary Tract Infection in Young Febrile Children: An Individual Patient Data Meta-Analysis.The Journal of pediatrics · 2023Pooled it
- Neutrophil gelatinase-associated lipocalin for urinary tract infection and pyelonephritis: a systematic review.Pediatric nephrology (Berlin, Germany) · 2021Pooled it
- Neutrophil gelatinase-associated lipocalin as predictor of acute kidney injury in neonates with perinatal asphyxia: a systematic review and meta-analysis.European journal of pediatrics · 2018Pooled it
- Identification of clinical and urine biomarkers for uncomplicated urinary tract infection using machine learning algorithms.Scientific reports · 2019Trial
- Potential Utility of Combined Urine Lipocalin‑2 and Copper Test in Diagnosing Acute Pyelonephritis or Cystitis.ACS omega · 2025Article
- Accuracy of Screening Tests for the Diagnosis of Urinary Tract Infections in Young Children.Pediatrics · 2024Article
- Assessment of urine calprotectin and YKL-40 levels in urinary tract infection diagnosis in children under 2 years of age.Scientific reports · 2024Article
- Biomarkers for urinary tract infection: present and future perspectives.Pediatric nephrology (Berlin, Germany) · 2024Review
- Plasma and Urinary Neutrophil Gelatinase-Associated Lipocalin as Predictors of Renal Parenchymal Involvement in Children with Febrile Urinary Tract Infection: A Pilot Study.Children (Basel, Switzerland) · 2024Article
- The Prevalence and Association of Different Uropathogens Detected by M-PCR with Infection-Associated Urine Biomarkers in Urinary Tract Infections.Research and reports in urology · 2024Article
- Biomarkers for febrile urinary tract infection in children.Frontiers in pediatrics · 2023Article
- Performance Evaluation of Host Biomarker Combinations for the Diagnosis of Serious Bacterial Infection in Young Febrile Children: A Double-Blind, Multicentre, Observational Study.Journal of clinical medicine · 2022Article
- Biomarkers in Pediatric Nephrology-From Bedside to Bench and Back Again.Journal of clinical medicine · 2022Article
- Urinary tract infections in children: Testing a novel, noninvasive, point-of-care diagnostic marker.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2022Article
- Biomarkers for febrile urinary tract infection in children.Pediatric nephrology (Berlin, Germany) · 2022Article
- Early postoperative urinary MCP-1 as a potential biomarker predicting acute rejection in living donor kidney transplantation: a prospective cohort study.Scientific reports · 2021Article
- Are Tubular Injury Markers NGAL and KIM-1 Useful in Pediatric Neurogenic Bladder?Journal of clinical medicine · 2021Article
- Associations of Plasma Neutrophil Gelatinase-associated Lipocalin, Anemia, and Renal Scarring in Children with Febrile Urinary Tract Infections.Journal of Korean medical science · 2020Article
- Biomarkers that differentiate false positive urinalyses from true urinary tract infection.Pediatric nephrology (Berlin, Germany) · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUrine biomarkers are commonly used in the evaluation of acute kidney injury, and are gaining attention as tools for studying urinary tract infections (UTIs). We analyzed neutrophil gelatinase-associated lipocalin (NGAL) and seven other urine biomarkers to evaluate their usefulness in the diagnosis of UTI in infants.
methodsEight urine biomarkers were analyzed in 108 infants with UTI. Controls were 64 febrile children without UTI and 13 healthy children. Logistic regression and construction of receiver operating characteristic (ROC) curves were performed for UTI patients versus febrile controls for all biomarkers.
resultsThe best biomarkers to differentiate between UTI and febrile controls were NGAL and interleukin 8 (IL8). Urine NGAL in absolute concentration and adjusted for creatinine had a sensitivity of 93% and 96% and a specificity of 95% and 100% for diagnosing UTI, with a cut-off concentration of 38 ng/mL and 233 ng/mg respectively.
conclusionsUrine biomarkers, particularly NGAL, can aid in the diagnosis of UTI among febrile infants. The results suggest that in infants with fever and high NGAL, UTI is most likely, whereas in infants with fever and low NGAL, other causes of fever should be looked for.
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