Evidence map›Paper›PMID 28756462›Full record

ArticlePsychopharmacology2017

Effects of GABA-B receptor positive modulator on ketamine-induced psychosis-relevant behaviors and hippocampal electrical activity in freely moving rats.

Jingyi Ma, L Stan Leung

Abstract read
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. GABAMedComm · 2025
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jingyi MaDepartment of Physiology and Pharmacology, The University of Western Ontario, Medical Sciences Building, London, ON, N6A 5C1, Canada. jma2@uwo.ca.
L Stan LeungDepartment of Physiology and Pharmacology, The University of Western Ontario, Medical Sciences Building, London, ON, N6A 5C1, Canada.
Western University · CA

Funding

Natural Sciences and Engineering Research Council of Canada (1037-2013) 1037-2013the Canadian Institutes of Health Research (MOP-15685). MOP-15685
6 · The paper itself

Abstract

rationaleDecreased GABA

objectivesIn this study, we tested the effect of CGP7930, a GABA

methodsElectrodes were bilaterally implanted into the hippocampus, and cannulae were placed into the lateral ventricles of Long-Evans rats. CGP7930 or vehicle was injected intraperitoneally (i.p.) or intracerebroventricularly (i.c.v.), alone or 15 min prior to ketamine (3 mg/kg, subcutaneous) injection. Paired click auditory evoked potentials in the hippocampus (AEP), prepulse inhibition (PPI), and locomotor activity were recorded before and after drug injection.

resultsCGP7930 at doses of 1 mg/kg (i.p.) prevented ketamine-induced deficit of PPI. CGP7930 (1 mg/kg i.p.) also prevented the decrease in gating of hippocampal AEP and the increase in hippocampal gamma (65-100 Hz) waves induced by ketamine. Unilateral i.c.v. infusion of CGP7930 (0.3 mM/1 μL) also prevented the decrease in gating of hippocampal AEP induced by ketamine. Ketamine-induced behavioral hyperlocomotion was suppressed by 5 mg/kg i.p. CGP7930. CGP7930 alone, without ketamine, did not significantly affect integrated PPI, locomotion, gating of hippocampal AEP, or gamma waves. CGP7930 (1 mg/kg i.p.) increased heterosynaptically mediated paired pulse depression in the hippocampus, a measure of GABA

conclusionsCGP7930 reduces the behavioral and electrophysiological disruptions induced by ketamine in animals, and the hippocampus may be one of the neural targets where CGP7930 exerts its actions.

Indexed as

Anesthetics, DissociativeAnimalsEvoked Potentials, AuditoryGABA-B Receptor AgonistsHippocampusKetamineMaleMotor ActivityPhenolsPrepulse InhibitionPsychoses, Substance-InducedRatsRats, Long-EvansReceptors, GABA-B2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenolAnesthetics, DissociativeGABA-B Receptor AgonistsKetaminePhenolsReceptors, GABA-BCGP7930GABAB receptor modulatorGating of hippocampal auditory evoked potentialsKetaminePrepulse inhibitionSchizophrenia

Identifiers

PMID28756462
OpenAlexW2740977377

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.