Evidence map›Paper›PMID 28755852›Full record

ArticleToxicon : official journal of the International Society on Toxinology2017

Noxious newts and their natural enemies: Experimental effects of tetrodotoxin exposure on trematode parasites and aquatic macroinvertebrates.

Dana M Calhoun, Gary M Bucciarelli, Lee B Kats, Richard K Zimmer, Pieter T J Johnson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicon : official journal of the International Society on Toxinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Dana M CalhounUniversity of Colorado Boulder, Department of Ecology and Evolutionary Biology, Ramaley N122, CB334, Boulder, CO 80309, USA. Electronic address: dana.calhoun@colorado.edu.
Gary M BucciarelliUniversity of California, Los Angeles, Department of Ecology and Evolutionary Biology, 610 Charles E. Young Dr. East, Los Angeles, CA 90095, USA; University of California, Los Angeles, La Kretz Center for California Conservation Science, Institute of the Environmental Sustainability, La Kretz Hall, Los Angeles, CA 90095, USA. Electronic address: garyb@ucla.edu.
Lee B KatsPepperdine University, Natural Science Division Pacific Coast Highway, Malibu, CA 90263, USA. Electronic address: lee.kats@pepperdine.edu.
Richard K ZimmerUniversity of California, Los Angeles, Department of Ecology and Evolutionary Biology, 610 Charles E. Young Dr. East, Los Angeles, CA 90095, USA; University of Queensland, Moreton Bay Research Station, Centre for Marine Sciences, School of Biological Sciences, Dunwich, Queensland 4183, Australia. Electronic address: z@biology.ucla.edu.
Pieter T J JohnsonUniversity of Colorado Boulder, Department of Ecology and Evolutionary Biology, Ramaley N122, CB334, Boulder, CO 80309, USA. Electronic address: pieter.johnson@colorado.edu.
University of Colorado Boulder · USPepperdine University · USUniversity of California, Los Angeles · USUniversity of Queensland · AU

Funding

EID disease in complex communities: multi-host multi-pathogen interactionsR01GM109499 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI BRIGGS, CHERYL J · 2013 to 2016
$1.7M
NIGMS NIH HHS R01 GM109499
6 · The paper itself

Abstract

The dermal glands of many amphibian species secrete toxins or other noxious substances as a defense strategy against natural enemies. Newts in particular possess the potent neurotoxin tetrodotoxin (TTX), for which the highest concentrations are found in species within the genus Taricha. Adult Taricha are hypothesized to use TTX as a chemical defense against vertebrate predators such as garter snakes (Thamnophis spp.). However, less is known about how TTX functions to defend aquatic-developing newt larvae against natural enemies, including trematode parasites and aquatic macroinvertebrates. Here we experimentally investigated the effects of exogenous TTX exposure on survivorship of the infectious stages (cercariae) of five species of trematode parasites that infect larval amphibians. Specifically, we used dose-response curves to test the sensitivity of trematode cercariae to progressively increasing concentrations of TTX (0.0 [control], 0.63, 3.13, 6.26, 31.32, and 62.64 nmol L

Indexed as

AnimalsInsectaLarvaPredatory BehaviorSalamandridaeTetrodotoxinTrematodaTetrodotoxinAmphibian declineAnimal toxicityInfectious diseaseNatural enemy ecologyTetrodotoxin

Identifiers

PMID28755852
PMCPMC5578716
OpenAlexW2738886316

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.