ReviewJournal of orthopaedic research : official publication of the Orthopaedic Research Society2018
The role of mechanobiology in progression of rotator cuff muscle atrophy and degeneration.
Review in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 59 citations in OpenAlex.
- Matrix stiffness induces midnolin-dependent lamin B1 degradation to control myoblast differentiation.EMBO reports · 2026Article
- Association between rotator cuff muscle cross-sectional area and dorsal scapular artery blood flow velocity in patients with rotator cuff tears.JSES reviews, reports, and techniques · 2026Article
- Supraspinatus Muscle Degeneration, Inflammation, and Regeneration Vary By Location in a Rat Model of Severe Rotator Cuff Tear.Regenerative engineering and translational medicine · 2026Article
- Effect of alpha-tocopherol and OTR-4131 on muscle degeneration after rotator cuff tear in rats: An experimental protocol.World journal of methodology · 2025Article
- Intramuscular adipose tissue restricts functional muscle recovery.Cell reports · 2025Article
- Inflammatory Cell Interactions in the Rotator Cuff Microenvironment: Insights From Single-Cell Sequencing.International journal of genomics · 2025Review
- The Suprascapular Artery as a Reference for the Evaluation of Supraspinatus Fatty Infiltration on Magnetic Resonance Imaging.Orthopaedic journal of sports medicine · 2024Article
- Dispase/collagenase cocktail allows for coisolation of satellite cells and fibroadipogenic progenitors from human skeletal muscle.American journal of physiology. Cell physiology · 2024Article
- Effect of Platelet-Rich Plasma at Different Initiation Times on Healing of the Bone-Tendon Interface of the Rotator Cuff in a Mouse Model.Orthopaedic journal of sports medicine · 2024Article
- Synergistic Effect of Hydrogen and 5-Aza on Myogenic Differentiation through the p38 MAPK Signaling Pathway in Adipose-Derived Mesenchymal Stem Cells.International journal of stem cells · 2023Article
- Histological, radiological and clinical analysis of the supraspinatus tendon and muscle in rotator cuff tears.BMC musculoskeletal disorders · 2023Article
- Clinical efficacy and tendon integrity of patients with subscapularis tear by the technique of arthroscopic single external row repair.Frontiers in medicine · 2023Article
- Progression of muscle loss and fat accumulation in a rabbit model of rotator cuff tear.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Transplant of Autologous Mesenchymal Stem Cells Halts Fatty Atrophy of Detached Rotator Cuff Muscle After Tendon Repair: Molecular, Microscopic, and Macroscopic Results From an Ovine Model.The American journal of sports medicine · 2021Article
- Transcriptional Time Course After Rotator Cuff Tear.Frontiers in physiology · 2021Article
- Proteomic analysis reveals rotator cuff injury caused by oxidative stress.Therapeutic advances in chronic disease · 2021Article
- MicroRNA-29a Mitigates Subacromial Bursa Fibrosis in Rotator Cuff Lesion with Shoulder Stiffness.International journal of molecular sciences · 2019Article
- Heterogeneous muscle gene expression patterns in patients with massive rotator cuff tears.PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Rotator cuff (RC) muscles undergo several detrimental changes following mechanical unloading resulting from RC tendon tear. In this review, we highlight the pathological causes and consequences of mechanical alterations at the whole muscle, muscle fiber, and muscle resident cell level as they relate to RC disease progression. In brief, the altered mechanical loads associated with RC tear lead to architectural, structural, and compositional changes at the whole-muscle and muscle fiber level. At the cellular level, these changes equate to direct disruption of mechanobiological signaling, which is exacerbated by mechanically regulated biophysical and biochemical changes to the cellular and extra-cellular environment (also known as the stem cell "niche"). Together, these data have important implications for both pre-clinical models and clinical practice. In pre-clinical models, it is important to recapitulate both the atrophic and degenerative muscle loss found in humans using clinically relevant modes of injury. Clinically, understanding the mechanics and underlying biology of the muscle will impact both surgical decision-making and rehabilitation protocols, as interventions that may be good for atrophic muscle will have a detrimental effect on degenerating muscle, and vice versa. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:546-556, 2018.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.