Evidence map›Paper›PMID 28755444›Full record

Trial reportDiabetic medicine : a journal of the British Diabetic Association2018

Bolusing frequency and amount impacts glucose control during hybrid closed-loop.

L Bally, H Thabit, Y Ruan, J K Mader, H Kojzar, S Dellweg, C Benesch, S Hartnell, L Leelarathna, M E Wilinska and 4 more

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetic medicine : a journal of the British Diabetic Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Bolusing frequency and amount impacts glucose control during hybrid closed-loop.Diabetic medicine : a journal of the British Diabetic Association · 2018
    Trial
  2. Article
  3. Review
  4. Review
  5. A Systematic Review of Commercial Hybrid Closed-Loop Automated Insulin Delivery Systems.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2023 · on this map
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

L BallyWellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
H ThabitWellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID 0000-0001-6076-6997
Y RuanWellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
J K MaderDepartment of Internal Medicine, Division of Endocrinology & Diabetology, Medical University of Graz, Graz, Austria.
H KojzarDepartment of Internal Medicine, Division of Endocrinology & Diabetology, Medical University of Graz, Graz, Austria.
S DellwegProfil Institut fuer Stoffwechselforschung GmbH, Neuss, Germany.
C BeneschProfil Institut fuer Stoffwechselforschung GmbH, Neuss, Germany.
S HartnellDepartment of Diabetes & Endocrinology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
L LeelarathnaCentral Manchester University Hospitals NHS foundation Trust and University of Manchester, Manchester, UK.ORCID 0000-0001-9602-1962
M E WilinskaWellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
M L EvansWellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
S ArnoldsProfil Institut fuer Stoffwechselforschung GmbH, Neuss, Germany.
T R PieberDepartment of Internal Medicine, Division of Endocrinology & Diabetology, Medical University of Graz, Graz, Austria.
R HovorkaWellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID 0000-0003-2901-461X

Funding

USC Resource Center for Minority Aging Research (US-RCMAR)P30AG043073 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EMMA AGUILA, JENNIFER A AILSHIRE · 2012 to 2026
$10.1M
One year day-and-night home closed loop in young people with type 1 diabetesUC4DK108520 · NIDDK · UNIVERSITY OF CAMBRIDGE · PI BERGENSTAL, RICHARD MAURITZ, BUCKINGHAM, BRUCE A · 2015 to 2015
$6.3M
24/7 closed-loop in older subjects with type 1 diabetesDP3DK112176 · NIDDK · UNIVERSITY OF CAMBRIDGE · PI HOVORKA, ROMAN · 2016 to 2016
$1.9M
Department of Health 14/23/09Department of Health EME/14/23/09NIA NIH HHS P30 AG043073NIDDK NIH HHS DP3 DK112176NIDDK NIH HHS UC4 DK108520Wellcome TrustWellcome Trust 100574/Z/12/Z
6 · The paper itself

Abstract

aimTo compare bolus insulin delivery patterns during closed-loop home studies in adults with suboptimally [HbA

methodsRetrospective analysis of daytime and night-time insulin delivery during home use of closed-loop over 4 weeks. Daytime and night-time controller effort, defined as amount of insulin delivered by closed-loop relative to usual basal insulin delivery, and daytime bolus effort, defined as total bolus insulin delivery relative to total daytime insulin delivery were compared between both cohorts. Correlation analysis was performed between individual bolus behaviour (bolus effort and frequency) and daytime controller efforts, and proportion of time spent within and below sensor glucose target range.

resultsIndividuals with suboptimally controlled Type 1 diabetes had significantly lower bolus effort (P = 0.038) and daily bolus frequency (P < 0.001) compared with those with well-controlled diabetes. Controller effort during both daytime (P = 0.007) and night-time (P = 0.005) were significantly higher for those with suboptimally controlled Type 1 diabetes. Time when glucose was within the target range (3.9-10.0 mmol/L) during daytime correlated positively with bolus effort (r = 0.37, P = 0.016) and bolus frequency (r = 0.33, P = 0.037). Time when glucose was below the target range during daytime was comparable in both groups (P = 0.36), and did not correlate significantly with bolus effort (r = 0.28, P = 0.066) or bolus frequency (r = -0.21, P = 0.19).

conclusionMore frequent bolusing and higher proportion of insulin delivered as bolus during hybrid closed-loop use correlated positively with time glucose was in target range. This emphasises the need for user input and educational support to benefit from this novel therapeutic modality.

Indexed as

AdultBlood GlucoseDiabetes Mellitus, Type 1FemaleGlycated HemoglobinHome Care ServicesHumansHypoglycemic AgentsInsulinInsulin Infusion SystemsMaleRetrospective StudiesBlood GlucoseGlycated HemoglobinHypoglycemic AgentsInsulin

Identifiers

PMID28755444
PMCPMC5788742

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.