Evidence map›Paper›PMID 28755277›Full record

ArticleTranslational stroke research2018

Chronic Remote Ischemic Conditioning Is Cerebroprotective and Induces Vascular Remodeling in a VCID Model.

Mohammad Badruzzaman Khan, Sherif Hafez, Md Nasrul Hoda, Babak Baban, Jesse Wagner, Mohamed E Awad, Hasith Sangabathula, Stephen Haigh, Mohammed Elsalanty, Jennifer L Waller and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational stroke research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.

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  11. A peripheral perspective on brain health: vascular and skeletal muscle contributions.American journal of physiology. Heart and circulatory physiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Mohammad Badruzzaman KhanDepartments of Neurology, Medical College of Georgia, Augusta University, 1120 15th Street, CA1053, Augusta, GA, 30912, USA. mkhan@augusta.edu.
Sherif HafezDepartments of Neurology, Medical College of Georgia, Augusta University, 1120 15th Street, CA1053, Augusta, GA, 30912, USA.
Md Nasrul HodaDepartment of Medical Laboratory, Imagine and Radiologic Sciences, Augusta University, Augusta, GA, 30912, USA.
Babak BabanDepartment of Oral Biology, Augusta University, Augusta, GA, 30912, USA.
Jesse WagnerDepartments of Neurology, Medical College of Georgia, Augusta University, 1120 15th Street, CA1053, Augusta, GA, 30912, USA.
Mohamed E AwadDepartment of Oral Biology, Augusta University, Augusta, GA, 30912, USA.
Hasith SangabathulaDepartments of Neurology, Medical College of Georgia, Augusta University, 1120 15th Street, CA1053, Augusta, GA, 30912, USA.
Stephen HaighVascular Biology Center, Augusta University, Augusta, GA, 30912, USA.
Mohammed ElsalantyDepartment of Oral Biology, Augusta University, Augusta, GA, 30912, USA.
Jennifer L WallerDepartments of Biostatistics, Augusta University, Augusta, GA, 30912, USA.
David C HessDepartments of Neurology, Medical College of Georgia, Augusta University, 1120 15th Street, CA1053, Augusta, GA, 30912, USA. dhess@augusta.edu.
Augusta University · USAugusta University Health · US

Funding

Remote ischemic conditioning for neuroprotection in vascular cognitive impairmentR21NS090609 · NINDS · AUGUSTA UNIVERSITY · PI HESS, DAVID C. · 2015 to 2016
$760k
NIH/NINDS R21NS090609-01A1NINDS NIH HHS R21 NS090609
6 · The paper itself

Abstract

Vascular contributions to cognitive impairment and dementia (VCID) make up 50% of the cases of dementia. The purpose of this study was to determine the effect of chronic remote ischemic conditioning (C-RIC) on improving long-term (6 months) outcomes and cerebral blood flow (CBF) and collateral formation in a mouse model of VCID. Adult C57BL/6J male mice (10 weeks) were randomly assigned to four different groups: (1) sham-bilateral carotid artery stenosis (BCAS), (2) BCAS + sham RIC, (3) BCAS+C-RIC for 1 month (1MO), and (4) BCAS+C-RIC-4 months (4MO). CBF, cognitive impairment, and functional outcomes were performed up for 6 months after BCAS surgery. The expression of CD31, α-SMA, and myelin basic protein (MBP) was assessed by immunohistochemistry (IHC). Additional set of mice were randomized to sham, BCAS, and BCAS+C-RIC. The cerebrovascular angioarchitecture was studied with micro-CT. RIC therapy for either 1 or 4 months significantly improved CBF, new collateral formation, functional and cognitive outcomes, and prevented white matter damage. There was no difference between C-RIC for 1 or 4 months; IHC studies at 6 months showed an increase in brain CD31 and α-SMA expression indicating increased angiogenesis and MBP indicating preservation of white matter in animals receiving RIC. One month of daily RIC is as effective as 4 months of daily RIC in improving CBF, angiogenesis, and long-term functional outcomes (6 months) in a VCID model. This suggests that 1 month of RIC is sufficient to reduce cognitive impairment and induce beneficial cerebrovascular remodeling.

Indexed as

ActinsAngiographyAnimalsCerebrovascular CirculationCognitive DysfunctionCytokinesDementia, VascularDisease Models, AnimalGene Expression RegulationIschemic PreconditioningMacrophagesMaleMaze LearningMiceMice, Inbred C57BLMyelin Basic ProteinActinsalpha-smooth muscle actin, mouseCytokinesMyelin Basic ProteinNitritesAngiogenesis, collateral remodeling, white matter degenerationCerebral blood flow (CBF)Chronic remote ischemic conditioning (C-RIC)Vascular contributions to cognitive impairment and dementia (VCID)

Identifiers

PMID28755277
PMCPMC5750336
OpenAlexW2741477784

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.