ArticleInternational journal of legal medicine2018
As solid as a rock-comparison of CE- and MPS-based analyses of the petrosal bone as a source of DNA for forensic identification of challenging cranial bones.
Article in International journal of legal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Minimally invasive skeletal sampling for STR-based human identification in degraded marine remains.International journal of legal medicine · 2026Article
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- Computed tomography differentiation of compact and cancellous bone tissue in short and sesamoid bones.Radiology and oncology · 2025Article
- Forensic skeletal and molecular anthropology face to face: Combining expertise for identification of human remains.Annals of the New York Academy of Sciences · 2025Review
- Review
- Patellae as a source of DNA in forensic and archaeological analysis.International journal of legal medicine · 2025Article
- Article
- Evaluation of a New DNA Extraction Method on Challenging Bone Samples Recovered from a WWII Mass Grave.Genes · 2024Article
- Genetic sexing of subadult skeletal remains.Scientific reports · 2023Article
- Improving kinship probability in analysis of ancient skeletons using identity SNPs and MPS technology.International journal of legal medicine · 2023Article
- Article
- Comparison of DNA preservation between adult and non-adult ancient skeletons.International journal of legal medicine · 2022Article
- Cranial and Odontological Methods for Sex Estimation-A Scoping Review.Medicina (Kaunas, Lithuania) · 2022Article
- Article
- Sweet tooth: DNA profiling of a cranium from an isolated retained root fragment.Journal of forensic sciences · 2021Article
- Ancestry and phenotype predictions from touch DNA using massively parallel sequencing.International journal of legal medicine · 2021Article
- DNA typing from skeletal remains: a comparison between capillary electrophoresis and massively parallel sequencing platforms.International journal of legal medicine · 2020Article
- A novel, 4-h DNA extraction method for STR typing of casework bone samples.International journal of legal medicine · 2020Article
- Inter-laboratory study on standardized MPS libraries: evaluation of performance, concordance, and sensitivity using mixtures and degraded DNA.International journal of legal medicine · 2020Article
- Genome-Wide DNA from Degraded Petrous Bones and the Assessment of Sex and Probable Geographic Origins of Forensic Cases.Scientific reports · 2019Article
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Authors and funding
3 authors.
Funding
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Abstract
Short tandem repeat (STR) typing from skeletal remains can be a difficult task. Dependent on the environmental conditions of the provenance of the bones, DNA can be degraded and STR typing inhibited. Generally, dense and compact bones are known to preserve DNA better. Several studies already proved that femora and teeth have high DNA typing success rates. Unfortunately, these elements are not present in all cases involving skeletal remains. Processing partial or singular skeletal elements, it is favorable to select bone areas where DNA preservation is comparably higher. Especially, cranial bones are often accidentally discovered during criminal investigations. The cranial bone is composed of multiple parts. In this examination, we evaluated the potential of the petrous bone for human identification of skeletal remains in forensic case work. Material from different sections of eight unknown cranial bones and-where available-additionally other skeletal elements, collected at the DNA department of the Institute of Legal Medicine in Ulm, Germany, from 2010 to 2017, were processed with an optimized DNA extraction and STR typing strategy. The results highlight that STR typing from the petrous bones leads to reportable profiles in all individuals, even in cases where the analysis of the parietal bone failed. Moreover, the comparison of capillary electrophorese (CE) typing to massively parallel sequencing (MPS) analysis shows that MPS has the potential to analyze degraded human remains and is even capable to provide additional information about phenotype and ancestry of unknown individuals.
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