Evidence map›Paper›PMID 28755137›Full record

SynthesisLung2017

Comparative Meta-Analysis of the Efficacy of Once-Daily Fluticasone Furoate 100 µG Versus Twice-Daily Fluticasone Propionate 250 µG in Adolescents and Adults with Persistent Asthma.

Ryan Tomlinson, Daniel Parks, Alan Martin

2 registry-linked trialsAbstract readComparative StudyMeta-Analysis
In one paragraph

Synthesis in Lung, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00603278 phase2completednot on this map

A Randomized Double-Blind, Double Dummy, Placebo-Controlled, Parallel-Group, Multicenter Dose Ranging Study to Evaluate the Efficacy and Safety of GW685698X Inhalation Powder Once Daily and Fluticasone Propionate Inhalation Powder 250mcg Twice Daily Compared With Placebo for 8 Weeks in Adolescent and Adult Subjects With Persistent Asthma Symptomatic on Low-Dose ICS Therapy

TypeinterventionalSponsorGlaxoSmithKlineRan2007 to 2008Enrolled622ConditionsAsthmaArmsGW685698X, placebo
NCT01159912 phase3completednot on this map

A Randomised, Double-blind, Double-dummy, Placebo Controlled (With Rescue Medication), Multicenter Study to Evaluate the Efficacy and Safety of Fluticasone Furoate Inhalation Powder in the Treatment of Persistent Asthma in Adults and Adolescents.

TypeinterventionalSponsorGlaxoSmithKlineRan2010 to 2012Enrolled350ConditionsAsthmaArmsFluticasone propionate, Fluticasone furoate, Placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ryan TomlinsonRespiratory Clinical Discovery, GSK, 709 Swedeland Road, King of Prussia, Upper Merion, PA, 19406, USA. ryan.x.tomlinson@gsk.com.ORCID 0000-0002-7875-7607
Daniel ParksValue Evidence Analytics, GSK Upper Providence, 1250 South Collegeville Road, Collegeville, PA, 19426, USA.
Alan MartinValue Evidence Analytics, GSK, 1-3 Iron Bridge Rd, Uxbridge, UB11 1BT, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fluticasone furoate and fluticasone propionate are recommended options for prophylactic maintenance treatment of persistent asthma. Using data from two previous clinical studies (GSK studies: FFA109685/NCT00603278, FFA112059/NCT01159912), this meta-analysis compared change from baseline in clinic visit mean trough forced expiratory volume in 1 s (FEV

Indexed as

Administration, InhalationAdolescentAdultAndrostadienesAsthmaBronchodilator AgentsDrug Administration ScheduleFluticasoneForced Expiratory VolumeHumansTreatment OutcomeAndrostadienesBronchodilator AgentsFluticasonefluticasone furoateAsthmaFluticasone furoateFluticasone propionateForced expiratory volume in 1 sInhaled corticosteroidMeta-analysis

Identifiers

PMID28755137
PMCPMC5599475

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.