ArticleScientific reports2017
Oral exposure to arsenic causes hearing loss in young people aged 12-29 years and in young mice.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- Premature senescence is regulated by crosstalk among TFEB, the autophagy lysosomal pathway and ROS derived from damaged mitochondria in NaAsOCell death discovery · 2024Article
- Association between urinary arsenic and hearing threshold shifts in adults in the United States, National Health and Nutrition Examination Survey, 2015-2016.Frontiers in public health · 2024Article
- Elevated arsenic level in fasting serum via ingestion of fish meat increased the risk of hypertension in humans and mice.European heart journal open · 2023Article
- Multidisciplinary approach to assess the toxicities of arsenic and barium in drinking water.Environmental health and preventive medicine · 2020Review
- Hearing loss in humans drinking tube well water with high levels of iron in arsenic-polluted area.Scientific reports · 2019Article
- Improvement of balance in young adults by a sound component at 100 Hz in music.Scientific reports · 2018Article
- Clinical Symptoms, Neurological Signs, and Electrophysiological Findings in Surviving Residents with Probable Arsenic Exposure in Toroku, Japan.Archives of environmental contamination and toxicology · 2018Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is no information on the association between oral exposure to arsenic (As) and hearing loss in humans or mice. In this combined epidemiological study and experimental study, the association of oral exposure to As with hearing loss in people aged 12-29 years and young mice was examined. Subjects in the exposure group (n = 48), who were drinking tube well water contaminated with As, showed significantly higher risks of hearing loss at 4 kHz [odds ratio (OR) = 7.60; 95% confidence interval (CI): 1.56, 57.88], 8 kHz (OR = 5.00; 95% CI: 1.48, 18.90) and 12 kHz (OR = 8.72; 95% CI: 2.09, 47.77) than did subjects in the control group (n = 29). We next performed an experiment in which young mice were exposed to As via drinking water at 22.5 mg/L, which is a much greater concentration than that in human studies. The exposure group showed hearing loss and accumulation of As in inner ears. Ex vivo exposure of the organ of Corti from mice exposed to As significantly decreased the number of auditory neurons and fibers. Thus, our combined study showed that oral exposure to As caused hearing loss in young people and young mice.
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Registered trials
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