Evidence map›Paper›PMID 28754992›Full record

ArticleScientific reports2017

Observed crowding effects on Mycobacterium tuberculosis 2-trans-enoyl-ACP (CoA) reductase enzyme activity are not due to excluded volume only.

Mariane Rotta, Luis F S M Timmers, Carlos Sequeiros-Borja, Cristiano V Bizarro, Osmar N de Souza, Diogenes S Santos, Luiz A Basso

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Large cosolutes, small cosolutes, and dihydrofolate reductase activity.Protein science : a publication of the Protein Society · 2017
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mariane RottaInstituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB), Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.
Luis F S M TimmersLaboratório de Bioinformática, Modelagem e Simulação de Biossistemas (LABIO), Faculdade de Informática, PUCRS, Porto Alegre, RS, Brazil.
Carlos Sequeiros-BorjaLaboratório de Bioinformática, Modelagem e Simulação de Biossistemas (LABIO), Faculdade de Informática, PUCRS, Porto Alegre, RS, Brazil.
Cristiano V BizarroInstituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB), Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.
Osmar N de SouzaLaboratório de Bioinformática, Modelagem e Simulação de Biossistemas (LABIO), Faculdade de Informática, PUCRS, Porto Alegre, RS, Brazil.
Diogenes S SantosInstituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB), Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil. diogenes@pucrs.br.
Luiz A BassoInstituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB), Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil. luiz.basso@pucrs.br.ORCID 0000-0003-0903-2407
Pontifícia Universidade Católica do Rio Grande do Sul · BRInstituto de Ciências Farmacêuticas · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cellular milieu is a complex and crowded aqueous solution. Macromolecular crowding effects are commonly studied in vitro using crowding agents. The aim of the present study was to evaluate the effects, if any, of macromolecular synthetic crowding agents on the apparent steady-state kinetic parameters (K

Indexed as

Molecular Dynamics SimulationBacterial ProteinsMycobacterium tuberculosisOxidoreductasesPolysaccharidesSolventsBacterial ProteinsInhA protein, MycobacteriumOxidoreductasesPolysaccharidesSolvents

Identifiers

PMID28754992
PMCPMC5533716
OpenAlexW2739165502

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.