ArticleScientific reports2017
Metabolic syndrome is associated with an increased incidence of subclinical hypothyroidism - A Cohort Study.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Prevalence of overt hypothyroidism and subclinical hypothyroidism in metabolic syndrome: a systematic review and meta-analysis.BMC endocrine disorders · 2026Pooled it
- A systematic review and meta-analysis investigating the relationship between metabolic syndrome and the incidence of thyroid diseases.Endocrine · 2024Pooled it
- Metabolic syndrome and risk of subclinical hypothyroidism: a systematic review and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Hypothyroidism: playing the cardiometabolic risk concerto.Thyroid research · 2025Review
- Association Between Metabolic Syndrome and Subclinical Hypothyroidism: A Systematic Review.Cureus · 2025Review
- Prevalence and associated factors of anxiety and depression among patients with hypothyroidism in Southern Iran.BMC psychiatry · 2025Article
- Relationship between plasma atherogenic index and subclinical hypothyroidism: an analysis of NHANES data and animal experiment.Frontiers in endocrinology · 2025Article
- Postprandial triglyceride levels affecting postprandial thyroid stimulating hormone levels may be responsible for the increased postprandial thyroid stimulating hormone levels in people with reduced lipid tolerance.Frontiers in endocrinology · 2025Article
- Relationship between sleep abnormalities and hypothyroidism: results from the National Health and Nutrition Examination Survey 2007-2012.BMC public health · 2024Article
- Association of subclinical hypothyroidism with metabolic syndrome and its components among outpatients with first-episode drug-naïve major depressive disorder: a large-scale cross-sectional study.European archives of psychiatry and clinical neuroscience · 2024Article
- Body mass index as a dominant risk factor for metabolic syndrome among indonesian adults: a 6-year prospective cohort study of non-communicable diseases.BMC nutrition · 2024Article
- Overall, sex-and race/ethnicity-specific prevalence of thyroid dysfunction in US adolescents aged 12-18 years.Frontiers in public health · 2024Article
- Cardiometabolic-related dietary patterns and thyroid function: a population-based cross-sectional study.European journal of medical research · 2023Article
- Prevalence and factors associated with metabolic syndrome in first hospitalization for major depression disorder patients.Scientific reports · 2023Article
- Association of subclinical hypothyroidism with metabolic syndrome components in a group of apparently healthy Syrians: a retrospective cross-sectional study.Annals of medicine and surgery (2012) · 2023Article
- Association between different metabolic phenotypes and the development of hypothyroidism: 9 years follow-up of Tehran thyroid study.Frontiers in endocrinology · 2023Article
- Association between thyroid dysfunction, metabolic disturbances, and clinical symptoms in first-episode, untreated Chinese patients with major depressive disorder: Undirected and Bayesian network analyses.Frontiers in endocrinology · 2023Article
- Nickel as a potential disruptor of thyroid function: benchmark modelling of human data.Frontiers in endocrinology · 2023Article
- Iodine Status in Pregnant Women Having Urinary Fluoride in Contaminated Areas: A Case Study of Phayao Province.Journal of environmental and public health · 2023Article
- Association of longitudinal changes in serum lipids with the natural history of subclinical hypothyroidism: A retrospective cohort study using data from the REACTION study.EClinicalMedicine · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prior cross-sectional analyses have demonstrated an association between subclinical hypothyroidism and metabolic syndrome and selected components. However, the temporal relation between metabolic syndrome and declining thyroid function remains unclear. In a prospective study, an unselected cohort of 66,822 participants with and without metabolic syndrome were followed. A proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% CIs for hypothyroidism. Exploratory analyses for the relation between components of metabolic syndrome and declining thyroid function were also undertaken. During an average follow-up of 4.2 years, the incident rates for subclinical hypothyroidism were substantially higher in participants who began the study with metabolic syndrome compared with metabolically normal controls. After controlling for risk factors, patients with metabolic syndrome were at a 21% excess risk of developing subclinical hypothyroidism (adjusted HR 1.21; 95% CI 1.03-1.42). When individual components were analyzed, an increased risk of subclinical hypothyroidism was associated with high blood pressure (1.24; 1.04-1.48) and high serum triglycerides (1.18; 1.00-1.39), with a trend of increasing risk as participants had additional more components. Individuals with metabolic syndrome are at a greater risk for developing subclinical hypothyroidism, while its mechanisms and temporal consequences of this observation remain to be determined.
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