ArticleNature chemistry2017
Design of multi-phase dynamic chemical networks.
Article in Nature chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Peptide-based artificial cytoskeleton enhances colocalized cascade reactions in cell-like microreactors.Chemical science · 2026Article
- Pathway selection between click and acyl transfer reactions driven by aminoacyl phosphates.Nature communications · 2026Article
- Emergent properties of supramolecular peptide assemblies.Chemical communications (Cambridge, England) · 2026Review
- Feedback driven autonomous cycles of assembly and disassembly from minimal building blocks.Nature communications · 2024Article
- Topological indices and patterns in iron telluride networks.Scientific reports · 2024Article
- Protometabolism as out-of-equilibrium chemistry.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2022Review
- Hierarchical self-assembly of aromatic peptide conjugates into supramolecular polymers: it takes two to tango.Chemical science · 2022Review
- Prebiotically Plausible Autocatalytic Peptide Amyloids.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Polyanion order controls liquid-to-solid phase transition in peptide/nucleic acid co-assembly.Frontiers in molecular biosciences · 2022Article
- Chemical control of peptide material phase transitions.Chemical science · 2021Article
- Solvent-driven chirality for luminescent self-assembled structures: experiments and theory.Nanoscale · 2020Article
- Systems Analysis for Peptide Systems Chemistry.Life (Basel, Switzerland) · 2019Article
- Methods for producing microstructured hydrogels for targeted applications in biology.Acta biomaterialia · 2019Review
- Amino-acid-encoded biocatalytic self-assembly enables the formation of transient conducting nanostructures.Nature chemistry · 2018Article
- Catalytic peptide assemblies.Chemical Society reviews · 2018Review
- Mechanism Insight into the Constitutional Phase Change Selection of Dynameric Framework Libraries.ACS omega · 2018Article
- Model-driven engineering of supramolecular buffering by multivalency.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Multistep Conformation Selection in Amyloid Assembly.Journal of the American Chemical Society · 2017Article
- Catalytic diversity in self-propagating peptide assemblies.Nature chemistry · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Template-directed polymerization reactions enable the accurate storage and processing of nature's biopolymer information. This mutualistic relationship of nucleic acids and proteins, a network known as life's central dogma, is now marvellously complex, and the progressive steps necessary for creating the initial sequence and chain-length-specific polymer templates are lost to time. Here we design and construct dynamic polymerization networks that exploit metastable prion cross-β phases. Mixed-phase environments have been used for constructing synthetic polymers, but these dynamic phases emerge naturally from the growing peptide oligomers and create environments suitable both to nucleate assembly and select for ordered templates. The resulting templates direct the amplification of a phase containing only chain-length-specific peptide-like oligomers. Such multi-phase biopolymer dynamics reveal pathways for the emergence, self-selection and amplification of chain-length- and possibly sequence-specific biopolymers.
Indexed as
Identifiers
28754943What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.