ArticleScientific reports2017
Scheduled feeding restores memory and modulates c-Fos expression in the suprachiasmatic nucleus and septohippocampal complex.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Circadian Interventions in Preclinical Models of Huntington's Disease: A Narrative Review.Biomedicines · 2024Review
- Reversible Suppression of Fear Memory Recall by Transient Circadian Arrhythmia.Frontiers in integrative neuroscience · 2022Article
- The Effect of Calorie Restriction and Intermittent Fasting on Impaired Cognitive Function in High-Fat Diet-Induced Obesity Started Post-Weaning in Male Wistar Rat.Medical journal of the Islamic Republic of Iran · 2022Article
- Impaired Morris water task retention following T21 light dark cycle exposure is not due to reduced hippocampal c-FOS expression.Frontiers in behavioral neuroscience · 2022Article
- Human circadian variations.The Journal of clinical investigation · 2021Review
- Signalling pathways contributing to learning and memory deficits in the Ts65Dn mouse model of Down syndrome.Neuronal signaling · 2021Review
- Disruption of circadian timing increases synaptic inhibition and reduces cholinergic responsiveness in the dentate gyrus.Hippocampus · 2021Article
- Suppression of Circadian Timing and Its Impact on the Hippocampus.Frontiers in neuroscience · 2021Review
- Article
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Authors and funding
6 authors.
Funding
Abstract
Disruptions in circadian timing impair spatial memory in humans and rodents. Circadian-arrhythmic Siberian hamsters (Phodopus sungorus) exhibit substantial deficits in spatial working memory as assessed by a spontaneous alternation (SA) task. The present study found that daily scheduled feeding rescued spatial memory deficits in these arrhythmic animals. Improvements in memory persisted for at least 3 weeks after the arrhythmic hamsters were switched back to ad libitum feeding. During ad libitum feeding, locomotor activity resumed its arrhythmic state, but performance on the SA task varied across the day with a peak in daily performance that corresponded to the previous daily window of food anticipation. At the end of scheduled feeding, c-Fos brain mapping revealed differential gene expression in entrained versus arrhythmic hamsters in the suprachiasmatic nucleus (SCN) that paralleled changes in the medial septum and hippocampus, but not in other neural structures. These data show that scheduled feeding can improve cognitive performance when SCN timing has been compromised, possibly by coordinating activity in the SCN and septohippocampal pathway.
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Registered trials
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