Evidence map›Paper›PMID 28754889›Full record

ArticleNature communications2017

Genetic and neuronal mechanisms governing the sex-specific interaction between sleep and sexual behaviors in Drosophila.

Dandan Chen, Divya Sitaraman, Nan Chen, Xin Jin, Caihong Han, Jie Chen, Mengshi Sun, Bruce S Baker, Michael N Nitabach, Yufeng Pan

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 103 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Sleep regulation inFrontiers in neuroscience · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Activity Monitoring for Analysis of Sleep inCold Spring Harbor protocols · 2024
    Article
  9. Article
  10. Article
  11. A neural pathway for social modulation of spontaneous locomotor activity (SoMo-SLA) inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Dandan ChenThe Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences, Southeast University, Nanjing, 210096, China.
Divya SitaramanJanelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia, 20147, USA. dsitaraman@sandiego.edu.
Nan ChenJanelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia, 20147, USA.
Xin JinDepartment of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, Connecticut, 06520, USA.
Caihong HanThe Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences, Southeast University, Nanjing, 210096, China.
Jie ChenThe Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences, Southeast University, Nanjing, 210096, China.
Mengshi SunThe Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences, Southeast University, Nanjing, 210096, China.
Bruce S BakerJanelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia, 20147, USA.
Michael N NitabachJanelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia, 20147, USA. michael.nitabach@yale.edu.
Yufeng PanThe Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences, Southeast University, Nanjing, 210096, China. pany@seu.edu.cn.
Southeast University · CNJanelia Research Campus · USYale University · USHelix (United States) · USNantong University · CN

Funding

Synaptic Microcircuits Underlying Associative LearningR01NS091070 · NINDS · YALE UNIVERSITY · PI NITABACH, MICHAEL · 2014 to 2024
$4.0M
Transgenic Tethered Spider ToxinsR01NS056443 · NINDS · YALE UNIVERSITY · PI NITABACH, MICHAEL · 2006 to 2014
$3.4M
Peptide Modulation of Physiology and BehaviorR01GM098931 · NIGMS · YALE UNIVERSITY · PI NITABACH, MICHAEL · 2011 to 2019
$3.0M
Calcium Signaling in Circadian Clock NeuronsR01NS055035 · NINDS · YALE UNIVERSITY · PI NITABACH, MICHAEL · 2008 to 2012
$1.8M
Dopamine regulation of sleep and arousalR15GM125073 · NIGMS · UNIVERSITY OF SAN DIEGO · PI SITARAMAN, DIVYA · 2017 to 2025
$951k
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM098931NIGMS NIH HHS R15 GM125073NINDS NIH HHS R01 NS055035NINDS NIH HHS R01 NS056443NINDS NIH HHS R01 NS091070
6 · The paper itself

Abstract

Animals execute one particular behavior among many others in a context-dependent manner, yet the mechanisms underlying such behavioral choice remain poorly understood. Here we studied how two fundamental behaviors, sex and sleep, interact at genetic and neuronal levels in Drosophila. We show that an increased need for sleep inhibits male sexual behavior by decreasing the activity of the male-specific P1 neurons that coexpress the sex determination genes fru

Indexed as

AnimalsCourtshipDNA-Binding ProteinsDrosophila melanogasterDrosophila ProteinsFemaleMaleNerve Tissue ProteinsNeuronsSex CharacteristicsSexual Behavior, AnimalSleepTranscription FactorsDNA-Binding ProteinsDrosophila ProteinsDSX protein, Drosophilafru protein, DrosophilaNerve Tissue ProteinsTranscription Factors

Identifiers

PMID28754889
PMCPMC5533705
OpenAlexW2736674683

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.