Evidence map›Paper›PMID 28754781›Full record

ArticlePhysiological reports2017

Nongenomic modulation of the large conductance voltage- and Ca

Kiril L Hristov, Shankar P Parajuli, Aaron Provence, Eric S Rovner, Georgi V Petkov

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
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  5. Article
  6. Detrusor Smooth Muscle KFrontiers in physiology · 2020
    Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kiril L HristovDepartment of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, South Carolina.
Shankar P ParajuliDepartment of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, South Carolina.
Aaron ProvenceDepartment of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, South Carolina.
Eric S RovnerMedical University of South Carolina, Charleston, South Carolina.
Georgi V PetkovDepartment of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, South Carolina gpetkov@uthsc.edu.
University of South Carolina · USMedical University of South Carolina · US

Funding

Role of TRP channels in human detrusor function and dysfunctionR01DK106964 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI XIN, WENKUAN · 2015 to 2019
$1.7M
BK Channel Function and Regulation in Urinary Bladder Smooth MuscleR01DK084284 · NIDDK · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI PETKOV, GEORGI V · 2009 to 2013
$1.6M
KCNQ Channels of the Urinary Bladder: A Functional Role and Therapeutic PotentialF31DK104528 · NIDDK · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI PROVENCE, AARON · 2014 to 2017
$95k
NIDDK NIH HHS F31 DK104528NIDDK NIH HHS R01 DK084284NIDDK NIH HHS R01 DK106964
6 · The paper itself

Abstract

Estrogens have an important role in regulating detrusor smooth muscle (DSM) function. However, the underlying molecular and cellular mechanisms by which estrogens control human DSM excitability and contractility are not well known. Here, we used human DSM specimens from open bladder surgeries on 27 patients to elucidate the mechanism by which 17

Indexed as

Action PotentialsAgedCells, CulturedEstradiolEstrogensFemaleHumansLarge-Conductance Calcium-Activated Potassium ChannelsMaleMuscle ContractionMyocytes, Smooth MuscleUrinary BladderEstradiolEstrogensLarge-Conductance Calcium-Activated Potassium Channels17β‐estradiolpatch‐clamppaxillineurinary bladder smooth muscle

Identifiers

PMID28754781
PMCPMC5532485
OpenAlexW2742156145

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.