Evidence map›Paper›PMID 28754779›Full record

ArticleGut2018

Genome-wide association study identifies inversion in the

Jonas Rosendahl, Holger Kirsten, Eszter Hegyi, Peter Kovacs, Frank Ulrich Weiss, Helmut Laumen, Peter Lichtner, Claudia Ruffert, Jian-Min Chen, Emmanuelle Masson and 78 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 6 pooled it
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 6 syntheses or guidelines pooled it, 131 citations in OpenAlex.

  1. Risk of chronic pancreatitis in carriers of the c.180C>T (p.Gly60=) CTRC variant: case-control studies and meta-analysis.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2023
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Role of the CommonGenes · 2020
    Pooled it
  6. Pooled it
  7. Article
  8. Article
  9. Personalizing treatment of pancreatitis-associated chronic pain: the need for an integrated omics approach.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
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  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Chronic and Idiopathic Pancreatitis-A Personalized Treatment Approach.United European gastroenterology journal · 2025
    Review
  18. Article
  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Commented on by
    The2018
5 · Who and what money

Authors and funding

88 authors at 20 institutions in 15 countries.

Jonas Rosendahl *Department of Internal Medicine I, Martin Luther University, Halle, Germany.
Holger Kirsten *Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
Eszter HegyiDepartment of Molecular and Cell Biology, Center for Exocrine Disorders, Boston University Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, USA.
Peter KovacsLeipzig University Medical Center, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.
Frank Ulrich WeissDepartment of Internal Medicine A, Ernst-Moritz-Arndt University, Greifswald, Germany.
Helmut LaumenElse Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany.
Peter LichtnerInstitute of Human Genetics, Helmholtz Centre Munich, German Research Centre for Environmental Health, Neuherberg, Germany.
Claudia RuffertDepartment of Internal Medicine I, Martin Luther University, Halle, Germany.
Jian-Min ChenInstitut National de la Santé et de la Recherche Médicale (INSERM) U1078; Etablissement Français du Sang (EFS) - Bretagne; Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale; Laboratoire de Génétique Moléculaire et d'Histocompatibilité, Centre Hospitalier Régional Universitaire (CHRU) Brest, Hôpital Morvan, Brest, France.
Emmanuelle MassonInstitut National de la Santé et de la Recherche Médicale (INSERM) U1078; Etablissement Français du Sang (EFS) - Bretagne; Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale; Laboratoire de Génétique Moléculaire et d'Histocompatibilité, Centre Hospitalier Régional Universitaire (CHRU) Brest, Hôpital Morvan, Brest, France.
Sebastian BeerDepartment of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology, University of Leipzig, Leipzig, Germany.
Constantin ZimmerDepartment of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology, University of Leipzig, Leipzig, Germany.
Katharina SeltsamDepartment of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology, University of Leipzig, Leipzig, Germany.
Hana AlgülDepartment of Gastroenterology, Technische Universität München (TUM), Munich, Germany.
Florence BühlerElse Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany.
Marco J BrunoDepartment of Gastroenterology & Hepatology, Erasmus Medical Centre, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
Peter BugertInstitute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Service of Baden-Württemberg, Mannheim, Germany.
Ralph BurkhardtLIFE- Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Giulia Martina CavestroDivision of Gastroenterology and Gastrointestinal Endoscopy, Vita Salute San Raffaele University - San Raffaele Scientific Institute, Milan, Italy.
Halina Cichoz-LachDepartment of Gastroenterology, Medical University of Lublin, Lublin, Poland.
Antoni FarréDepartment of Gastroenterology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Josef FrankDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
Giovanni GambaroDivision of Nephrology and Dialysis, Institute of Internal Medicine, Renal Program, Columbus-Gemelli University Hospital, Catholic University, Rome, Italy.
Sebastian GimpflElse Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany.
Harald GrallertResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Heidi GriesmannDepartment of Internal Medicine I, Martin Luther University, Halle, Germany.
Robert GrützmannUniversitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Chirurgische Klinik, Erlangen, Germany.
Claus HellerbrandDepartment of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany.
Péter HegyiInstitute for Translational Medicine and First Department of Internal Medicine, University of Pécs, Pécs, Hungary.
Marcus HollenbachDepartment of Internal Medicine I, Martin Luther University, Halle, Germany.
Sevastitia IordacheDepartment of Internal Medicine and Gastroenterology, University of Medicine and Pharmacy, Craiova, Romania.
Grazyna JurkowskaDepartment of Gastroenterology and Internal Medicine, Medical University Bialystok, Bialystok, Poland.
Volker KeimDepartment of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology, University of Leipzig, Leipzig, Germany.
Falk KieferDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
Sebastian KrugDepartment of Internal Medicine I, Martin Luther University, Halle, Germany.
Olfert LandtTIB MOLBIOL, Berlin, Germany.
Milena Di LeoDivision of Gastroenterology and Gastrointestinal Endoscopy, Vita Salute San Raffaele University - San Raffaele Scientific Institute, Milan, Italy.
Markus M LerchDepartment of Internal Medicine A, Ernst-Moritz-Arndt University, Greifswald, Germany.
Philippe LévyPôle des Maladies de l'Appareil Digestif, Service de Gastroentérologie-Pancréatologie, Hôpital Beaujon, AP-HP, Clichy, France.
Markus LöfflerInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
Matthias LöhrGastrocentrum, Karolinska Institutet CLINTEC, Stockholm, Sweden.
Maren LudwigElse Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany.
Milan MacekDepartment of Biology and Medical Genetics, University Hospital Motol and 2nd Faculty of Medicine, Charles University, Prague, Czech Republic.
Nuria MalatsGrupo de Epidemiología Genética y Molecular Programa de Genética del Cáncer Humano Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.
Ewa Malecka-PanasDepartment of Digestive Tract Diseases, Medical University of Łódź, Łódź, Poland.
Giovanni MalerbaBiology and Genetics, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy.
Karl MannDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
Julia MayerleDepartment of Medicine II, University Hospital,Ludwig-Maximilians-University Munich, Munich, Germany.
Sonja MohrElse Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany.
Rene H M Te MorscheDepartment of Gastroenterology and Hepatology, Radboud umc, Nijmegen, The Netherlands.
Marie MotykaElse Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany.
Sebastian MuellerDepartment of Internal Medicine, Salem Medical Centre and Centre for Alcohol Research, University of Heidelberg, Heidelberg, Germany.
Thomas MüllerDepartment of Pediatrics I, Medical University, Innsbruck, Austria.
Markus M NöthenDepartment of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
Sergio PedrazzoliDepartment of Medical and Surgical Sciences, IV Surgical Clinic, University of Padua, Padua, Italy.
Stephen P PereiraDivision of Medicine, UCL Institute for Liver and Digestive Health, University College London, London, UK.
Annette PetersInstitute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Roland PfützerClinic for Internal Medicine, Hospital Döbeln, Döbeln, Germany.
Francisco X RealCIBERONC, Spain.
Vinciane ReboursPôle des Maladies de l'Appareil Digestif, Service de Gastroentérologie-Pancréatologie, Hôpital Beaujon, AP-HP, Clichy, France.
Monika RidingerDepartment of Psychiatry, University of Regensburg, Regensburg, Germany.
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
Eva RösmannElse Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany.
Adrian SaftoiuDepartment of Internal Medicine and Gastroenterology, University of Medicine and Pharmacy, Craiova, Romania.
Alexander SchneiderDepartment of Gastroenterology, Hepatology, Infectious Diseases, Medical Faculty of Mannheim University of Heidelberg, Mannheim, Germany.
Hans-Ulrich SchulzDepartment of Surgery, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Nicole SoranzoThe Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
Michael SoykaPsychiatric Hospital, University of Munich, Munich, Germany.
Peter SimonDepartment of Internal Medicine A, Ernst-Moritz-Arndt University, Greifswald, Germany.
James SkipworthDepartment of Surgery and Interventional Science, University College London, London, UK.
Felix StickelDepartment of Gastroenterology and Hepatology, University Hospital of Zürich, Zürich, Switzerland.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Michael StumvollLeipzig University Medical Center, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.
Pier Alberto TestoniDivision of Gastroenterology and Gastrointestinal Endoscopy, Vita Salute San Raffaele University - San Raffaele Scientific Institute, Milan, Italy.
Anke TönjesDepartment of Internal Medicine, Neurology and Dermatology, Division of Endocrinology, University of Leipzig, Leipzig, Germany.
Lena WernerElse Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany.
Jens WernerDepartment of General, Visceral, and Transplant Surgery, Ludwig Maximilian University, Munich, Germany.
Norbert WodarzDepartment of Psychiatry, University of Regensburg, Regensburg, Germany.
Martin ZieglerElse Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany.
Atsushi MasamuneDivision of Gastroenterology, Tohoku University Graduate School of Medicine, SendaiMiyagi, Japan.
Joachim MössnerDepartment of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology, University of Leipzig, Leipzig, Germany.
Claude FérecInstitut National de la Santé et de la Recherche Médicale (INSERM) U1078; Etablissement Français du Sang (EFS) - Bretagne; Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale; Laboratoire de Génétique Moléculaire et d'Histocompatibilité, Centre Hospitalier Régional Universitaire (CHRU) Brest, Hôpital Morvan, Brest, France.
Patrick MichlDepartment of Internal Medicine I, Martin Luther University, Halle, Germany.
Joost P H DrenthDepartment of Gastroenterology and Hepatology, Radboud umc, Nijmegen, The Netherlands.
Heiko WittElse Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany.
Markus ScholzInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
Miklós Sahin-TóthDepartment of Molecular and Cell Biology, Center for Exocrine Disorders, Boston University Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, USA.
all members of the PanEuropean Working group on ACP
Technical University of Munich · DELeipzig University · DEMartin Luther University Halle-Wittenberg · DELudwig-Maximilians-Universität München · DEUniversität Greifswald · DEUniversity Hospital Heidelberg · DEVita-Salute San Raffaele University · ITBoston University · USElse Kröner-Fresenius-Stiftung · DEHeidelberg University · DEHelmholtz Zentrum München · DEIFB Adiposity Diseases · DERadboud University Medical Center · NLUniversity College London · GBUniversity of Medicine and Pharmacy of Craiova · ROUniversity of Regensburg · DEAgostino Gemelli University Polyclinic · ITAssistance Publique – Hôpitaux de Paris · FRCentral Institute of Mental Health · DECentre Hospitalier Régional Universitaire de Brest · FR

Funding

Chymotrypsin in pancreatitisR01DK082412 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAHIN-TOTH, MIKLOS · 2009 to 2024
$5.8M
Molecular Pathomechanism of Hereditary PancreatitisR01DK058088 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAHIN-TOTH, MIKLOS · 2001 to 2019
$5.3M
Pancreatic elastasesR01DK095753 · NIDDK · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SAHIN-TOTH, MIKLOS · 2013 to 2016
$1.4M
NIDDK NIH HHS R01 DK058088NIDDK NIH HHS R01 DK082412NIDDK NIH HHS R01 DK095753
6 · The paper itself

Abstract

objectiveAlcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic pancreatitis (CP) is poorly characterised. To identify risk genes for alcoholic CP and to evaluate their relevance in non-alcoholic CP, we performed a genome-wide association study and functional characterisation of a new pancreatitis locus.

design1959 European alcoholic CP patients and population-based controls from the KORA, LIFE and INCIPE studies (n=4708) as well as chronic alcoholics from the GESGA consortium (n=1332) were screened with Illumina technology. For replication, three European cohorts comprising 1650 patients with non-alcoholic CP and 6695 controls originating from the same countries were used.

resultsWe replicated previously reported risk loci

conclusionAn inversion in the

Indexed as

Pancreatitis, AlcoholicAdultAgedChymotrypsinEuropeFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedPolymorphism, Single NucleotideChymotrypsinchymotrypsin Bchronic pancreatitisgenetic rearrangementGenome wide association study

Identifiers

PMID28754779
PMCPMC6145291
OpenAlexW2741999340

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.