ArticleEMBO molecular medicine2017
Open access · goldAbstract read
In one paragraph
Article in EMBO molecular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 91 citations in OpenAlex.
- Fibroblast growth factor 21 and its relationship with central precocious puberty in girls.Endocrine connections · 2026Article
- Genetics of Idiopathic Hypogonadotropic HypogonadismJournal of clinical research in pediatric endocrinology · 2026Review
- The role of FGF21 in the metabolic adjustments required for exercise capacity.Life sciences · 2025Review
- Article
- Multiomics unravels the complexity of male obesity: a prospective observational study.Journal of translational medicine · 2025Observational
- Unveiling the Emerging Role of Klotho: A Comprehensive Narrative Review of an Anti-aging Factor in Human Fertility.Current protein & peptide science · 2025Review
- Mini-Puberty, Physiological and Disordered: Consequences, and Potential for Therapeutic Replacement.Endocrine reviews · 2024Review
- Defective FGFR1 Signaling Disrupts Glucose Regulation: Evidence From Humans WithJournal of the Endocrine Society · 2024Article
- Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra's seminal work.Nature reviews. Endocrinology · 2024Review
- SEMA6A drives GnRH neuron-dependent puberty onset by tuning median eminence vascular permeability.Nature communications · 2023Article
- Dietary Protein Regulates Female Estrous Cyclicity Partially via Fibroblast Growth Factor 21.Nutrients · 2023Article
- Defective jagged-1 signaling affects GnRH development and contributes to congenital hypogonadotropic hypogonadism.JCI insight · 2023Article
- Androgen increases klotho expression via the androgen receptor-mediated pathway to induce GCs apoptosis.Journal of ovarian research · 2023Article
- Article
- Biological and pharmacological functions of the FGF19- and FGF21-coreceptor beta klotho.Frontiers in endocrinology · 2023Review
- Convergent biological pathways underlying the Kallmann syndrome-linked genes Hs6st1 and Fgfr1.Human molecular genetics · 2022Article
- Genetics of pubertal delay.Clinical endocrinology · 2022Review
- Central FGF21 production regulates memory but not peripheral metabolism.Cell reports · 2022Article
- Glial cells as integrators of peripheral and central signals in the regulation of energy homeostasis.Nature metabolism · 2022Review
- Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21.Nature metabolism · 2022Article
Corrections and comments
- Commented on by
Authors and funding
26 authors at 13 institutions in 5 countries.
Cheng XuService of Endocrinology, Diabetology & Metabolism, Lausanne University Hospital, Lausanne, Switzerland.
Andrea MessinaService of Endocrinology, Diabetology & Metabolism, Lausanne University Hospital, Lausanne, Switzerland.
Emmanuel SommService of Endocrinology, Diabetology & Metabolism, Lausanne University Hospital, Lausanne, Switzerland.
Hichem MiraouiService of Endocrinology, Diabetology & Metabolism, Lausanne University Hospital, Lausanne, Switzerland.
Tarja KinnunenDepartment of Biology, School of Applied Sciences, University of Huddersfield, Huddersfield, UK.
James AciernoService of Endocrinology, Diabetology & Metabolism, Lausanne University Hospital, Lausanne, Switzerland.
Nicolas J NiederländerService of Endocrinology, Diabetology & Metabolism, Lausanne University Hospital, Lausanne, Switzerland.
Justine BouillyService of Endocrinology, Diabetology & Metabolism, Lausanne University Hospital, Lausanne, Switzerland.
Andrew A DwyerService of Endocrinology, Diabetology & Metabolism, Lausanne University Hospital, Lausanne, Switzerland.
Yisrael SidisService of Endocrinology, Diabetology & Metabolism, Lausanne University Hospital, Lausanne, Switzerland.
Daniele CassatellaService of Endocrinology, Diabetology & Metabolism, Lausanne University Hospital, Lausanne, Switzerland.
Gerasimos P SykiotisService of Endocrinology, Diabetology & Metabolism, Lausanne University Hospital, Lausanne, Switzerland.
Richard QuintonInstitute for Genetic Medicine, University of Newcastle-on-Tyne, Newcastle-on Tyne, UK.
Christian De GeyterClinic of Gynecological Endocrinology and Reproductive Medicine, University Hospital, University of Basel, Basel, Switzerland.
Mirjam DirlewangerPediatric Endocrine and Diabetes Unit, Children's Hospital, University Hospitals and Faculty of Medicine, Geneva, Switzerland.
Valérie SchwitzgebelPediatric Endocrine and Diabetes Unit, Children's Hospital, University Hospitals and Faculty of Medicine, Geneva, Switzerland.
Trevor R ColeDepartment of Clinical Genetics, Birmingham Women's Hospital, Birmingham, UK.
Andrew A ToogoodDepartment of Endocrinology, Queen Elizabeth Hospital, University Hospitals Birmingham, Birmingham, UK.
Jeremy Mw KirkDepartment of Endocrinology, Birmingham Children's Hospital, Birmingham, UK.
Lacey PlummerNational Center for Translational Research in Reproduction and Infertility, Harvard Reproductive Endocrine Sciences Center of the Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Urs AlbrechtDepartment of Biology, Biochemistry, Faculty of Science, University of Fribourg, Fribourg, Switzerland.ORCID 0000-0002-0663-8676
William F CrowleyNational Center for Translational Research in Reproduction and Infertility, Harvard Reproductive Endocrine Sciences Center of the Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Moosa MohammadiDepartment of Biochemistry & Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.
Manuel Tena-SempereDepartment of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain.
Vincent PrevotInserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, JPARC, Lille, France.
Nelly PitteloudService of Endocrinology, Diabetology & Metabolism, Lausanne University Hospital, Lausanne, Switzerland nelly.pitteloud@chuv.ch.ORCID 0000-0003-0971-3237
University of Lausanne · CHMassachusetts General Hospital · USUniversity Hospital of Geneva · CHBirmingham Children's Hospital · GBBirmingham Women's Hospital · GBInserm · FRInstituto de Salud Carlos III · ESNewcastle University · GBNew York University · USQueen Elizabeth Hospital Birmingham · GBUniversity of Basel · CHUniversity of Fribourg · CHUniversity of Huddersfield · GB
Funding
The Genetic Determinants of Human GNRH DeficiencyP50HD028138 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI SEMINARA, STEPHANIE BETH · 2014 to 2020
$12.9MMECHANISMS OF FGF RECEPTOR REGULATION AND SIGNALINGR01DE013686 · NIDCR · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MOHAMMADI, MOOSA · 2000 to 2020
$12.3MNational Centre for the Replacement, Refinement and Reduction of Animals in Research NC/M001717/1NICHD NIH HHS P50 HD028138NIDCR NIH HHS R01 DE013686
Abstract
Congenital hypogonadotropic hypogonadism (CHH) is a rare genetic form of isolated gonadotropin-releasing hormone (GnRH) deficiency caused by mutations in > 30 genes. Fibroblast growth factor receptor 1 (
Indexed as
AnimalsCaenorhabditis elegansChlorocebus aethiopsCohort StudiesCOS CellsFemaleFibroblast Growth FactorsGonadotropin-Releasing HormoneHEK293 CellsHumansHypothalamusKallmann SyndromeKlotho ProteinsMaleMembrane ProteinsMice, Inbred C57BLFGFR1 protein, humanfibroblast growth factor 21Fibroblast Growth FactorsGonadotropin-Releasing HormoneKLB protein, humanKlotho ProteinsMembrane ProteinsReceptor, Fibroblast Growth Factor, Type 1beta‐klothocongenital hypogonadotropic hypogonadismfibroblast growth factor 21fibroblast growth factor receptor 1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.